Effect of Weight Loss on Serum Osteocalcin and Its Association with Serum Adipokines
Joint Authors
Albadah, Mohammed S.
Shaik, Shaffi Ahamed
Alsaif, Mohammed A.
Shogair, Mustafa
Nawaz, Shahid
Alfadda, Assim A.
Dekhil, Hafedh
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Studies have suggested that osteocalcin, a bone formation marker, is related to body metabolism and insulin sensitivity.
Whether this relation is mediated through an interaction with adipokines remains unclear.
The aim of this study was to assess the effect of weight loss on serum osteocalcin and its relation with three adipokines, adiponectin, chemerin, and resistin.
Forty-nine obese nondiabetic males completed a four-month dietary program.
Body mass index (BMI) decreased significantly from 39.7±7.6 to 37.8±7.6 (P<0.001).
This was associated with significant reduction in waist circumference, fasting blood glucose, HOMA-IR, total and LDL-cholesterol, bone-specific alkaline phosphatase (BAP), and resistin (P<0.05).
There was significant increase in serum adiponectin and undercarboxylated osteocalcin (uOC) (P<0.001).
The changes in uOC levels were negatively correlated with changes in serum triglycerides (r=-0.51, P<0.001) and positively correlated with changes in BAP (r=0.52, P<0.001).
In contrast, the changes in uOC were not correlated with changes in BMI, waist circumference, fasting blood glucose, HOMA-IR, total and LDL-cholesterol, hsCRP, vitamin D, and circulating adipokines.
We concluded that the increase in serum uOC following weight loss is not related to the changes in circulating adipokines levels.
American Psychological Association (APA)
Albadah, Mohammed S.& Dekhil, Hafedh& Shaik, Shaffi Ahamed& Alsaif, Mohammed A.& Shogair, Mustafa& Nawaz, Shahid…[et al.]. 2015. Effect of Weight Loss on Serum Osteocalcin and Its Association with Serum Adipokines. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065722
Modern Language Association (MLA)
Albadah, Mohammed S.…[et al.]. Effect of Weight Loss on Serum Osteocalcin and Its Association with Serum Adipokines. International Journal of Endocrinology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1065722
American Medical Association (AMA)
Albadah, Mohammed S.& Dekhil, Hafedh& Shaik, Shaffi Ahamed& Alsaif, Mohammed A.& Shogair, Mustafa& Nawaz, Shahid…[et al.]. Effect of Weight Loss on Serum Osteocalcin and Its Association with Serum Adipokines. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065722
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065722