Differential Role of Leptin and Adiponectin in Cardiovascular System
Joint Authors
Ghantous, C. M.
Azrak, Z.
Hanache, S.
Abou-Kheir, W.
Zeidan, A.
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-03
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Leptin and adiponectin are differentially expressed adipokines in obesity and cardiovascular diseases.
Leptin levels are directly associated with adipose tissue mass, while adiponectin levels are downregulated in obesity.
Although significantly produced by adipocytes, leptin is also produced by vascular smooth muscle cells and cardiomyocytes.
Plasma leptin concentrations are elevated in cases of cardiovascular diseases, such as hypertension, congestive heart failure, and myocardial infarction.
As for the event of left ventricular hypertrophy, researchers have been stirring controversy about the role of leptin in this form of cardiac remodeling.
In this review, we discuss how leptin has been shown to play an antihypertrophic role in the development of left ventricular hypertrophy through in vitro experiments, population-based cross-sectional studies, and longitudinal cohort studies.
Conversely, we also examine how leptin may actually promote left ventricular hypertrophy using in vitro analysis and human-based univariate and multiple linear stepwise regression analysis.
On the other hand, as opposed to leptin’s generally detrimental effects on the cardiovascular system, adiponectin is a cardioprotective hormone that reduces left ventricular and vascular hypertrophy, oxidative stress, and inflammation.
In this review, we also highlight adiponectin signaling and its protective actions on the cardiovascular system.
American Psychological Association (APA)
Ghantous, C. M.& Azrak, Z.& Hanache, S.& Abou-Kheir, W.& Zeidan, A.. 2015. Differential Role of Leptin and Adiponectin in Cardiovascular System. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1065735
Modern Language Association (MLA)
Ghantous, C. M.…[et al.]. Differential Role of Leptin and Adiponectin in Cardiovascular System. International Journal of Endocrinology No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1065735
American Medical Association (AMA)
Ghantous, C. M.& Azrak, Z.& Hanache, S.& Abou-Kheir, W.& Zeidan, A.. Differential Role of Leptin and Adiponectin in Cardiovascular System. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1065735
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065735