Cardiovascular System Changes and Related Risk Factors in Acromegaly Patients: A Case-Control Study
Joint Authors
Guo, Xiaopeng
Gao, Lu
Zhang, Shuo
Li, Yilin
Wu, Yue
Fang, Ligang
Deng, Kan
Yao, Yong
Lian, Wei
Wang, Renzhi
Xing, Bing
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Cardiovascular complications are known to be the main determinants of reduced life expectancy and decreased quality of life in acromegaly patients.
Our study aimed to provide insight into the cardiovascular changes that occur in acromegaly patients and to investigate the correlative risk factors.
Methods.
A total of 108 patients definitively diagnosed with acromegaly and 108 controls matched for age and gender were recruited into study and control groups, respectively.
Standard echocardiography was performed on all of the participants, and data were collected and analyzed.
Results.
All acromegaly patients presented with structural cardiac changes, including a larger heart cavity, thicker myocardial walls, and increased great vessel diameters compared with the control group.
Additionally, the acromegaly patients presented with reduced diastolic function.
Aging and increased body mass index (BMI) were correlated with myocardial hypertrophy and diastolic dysfunction; a longer disease duration was correlated with larger great vessel diameters.
Conclusions.
Ageing and increased BMI are independent risk factors for acromegalic cardiomyopathy, and a long disease duration results in the expansion of great vessels.
Increased efforts should be made to diagnose acromegaly at an early stage and to advise acromegaly patients to maintain a healthy weight.
American Psychological Association (APA)
Guo, Xiaopeng& Gao, Lu& Zhang, Shuo& Li, Yilin& Wu, Yue& Fang, Ligang…[et al.]. 2015. Cardiovascular System Changes and Related Risk Factors in Acromegaly Patients: A Case-Control Study. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065750
Modern Language Association (MLA)
Guo, Xiaopeng…[et al.]. Cardiovascular System Changes and Related Risk Factors in Acromegaly Patients: A Case-Control Study. International Journal of Endocrinology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1065750
American Medical Association (AMA)
Guo, Xiaopeng& Gao, Lu& Zhang, Shuo& Li, Yilin& Wu, Yue& Fang, Ligang…[et al.]. Cardiovascular System Changes and Related Risk Factors in Acromegaly Patients: A Case-Control Study. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065750
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065750