A Role for Estrogen in Schizophrenia: Clinical and Preclinical Findings
Joint Authors
Gogos, Andrea
Sbisa, Alyssa M.
Sun, Jeehae
Gibbons, Andrew
Udawela, Madhara
Dean, Brian
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-27
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Gender differences in schizophrenia have been extensively researched and it is being increasingly accepted that gonadal steroids are strongly attributed to this phenomenon.
Of the various hormones implicated, the estrogen hypothesis has been the most widely researched one and it postulates that estrogen exerts a protective effect by buffering females against the development and severity of the illness.
In this review, we comprehensively analyse studies that have investigated the effects of estrogen, in particular 17β-estradiol, in clinical, animal, and molecular research with relevance to schizophrenia.
Specifically, we discuss the current evidence on estrogen dysfunction in schizophrenia patients and review the clinical findings on the use of estradiol as an adjunctive treatment in schizophrenia patients.
Preclinical research that has used animal models and molecular probes to investigate estradiol’s underlying protective mechanisms is also substantially discussed, with particular focus on estradiol’s impact on the major neurotransmitter systems implicated in schizophrenia, namely, the dopamine, serotonin, and glutamate systems.
American Psychological Association (APA)
Gogos, Andrea& Sbisa, Alyssa M.& Sun, Jeehae& Gibbons, Andrew& Udawela, Madhara& Dean, Brian. 2015. A Role for Estrogen in Schizophrenia: Clinical and Preclinical Findings. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1065761
Modern Language Association (MLA)
Gogos, Andrea…[et al.]. A Role for Estrogen in Schizophrenia: Clinical and Preclinical Findings. International Journal of Endocrinology No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1065761
American Medical Association (AMA)
Gogos, Andrea& Sbisa, Alyssa M.& Sun, Jeehae& Gibbons, Andrew& Udawela, Madhara& Dean, Brian. A Role for Estrogen in Schizophrenia: Clinical and Preclinical Findings. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1065761
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065761