The Clinicopathological Features of BRAF Mutated Papillary Thyroid Cancers in Chinese Patients
Joint Authors
Yang, Li-Bo
Sun, Lin-Yong
Jiang, Yong
Tang, Ying
Li, Zhi-Hui
Zhang, Hong-Ying
Bu, Hong
Ye, Feng
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The BRAFV600E mutation is commonly found in papillary thyroid cancers (PTCs) at different frequencies in different regions.
However, the association between the BRAFV600E mutation and clinicopathological features in Chinese PTC patients is unknown.
A total of 543 Chinese patients with histologically confirmed PTC were enrolled in this study.
For the BRAF mutation assay, the target fragments were amplified and sequenced with an ABI 3500 gene analyzer.
In 170 of 543 samples (31.3%), the BRAFV600E mutation was detected.
In the bivariate analysis, the BRAFV600E mutation showed an association with bilaterality, tumor size, extrathyroidal invasion, and lymph node metastases (LNM).
However, in the multivariate analysis, the BRAFV600E mutation was positively related to only tumor size (>1 cm) and extrathyroidal invasion.
In addition, the multivariate analysis also showed that the age at diagnosis (<45 y) and tumor size (>1 cm) were independent predictors for LNM.
In this study, the BRAFV600E mutation is positively associated with worse prognostic factors, including larger tumor size and the tumor extending to the thyroid capsule or extrathyroidal region; however, it is not an independent predictor for LNM.
American Psychological Association (APA)
Yang, Li-Bo& Sun, Lin-Yong& Jiang, Yong& Tang, Ying& Li, Zhi-Hui& Zhang, Hong-Ying…[et al.]. 2015. The Clinicopathological Features of BRAF Mutated Papillary Thyroid Cancers in Chinese Patients. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065768
Modern Language Association (MLA)
Yang, Li-Bo…[et al.]. The Clinicopathological Features of BRAF Mutated Papillary Thyroid Cancers in Chinese Patients. International Journal of Endocrinology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1065768
American Medical Association (AMA)
Yang, Li-Bo& Sun, Lin-Yong& Jiang, Yong& Tang, Ying& Li, Zhi-Hui& Zhang, Hong-Ying…[et al.]. The Clinicopathological Features of BRAF Mutated Papillary Thyroid Cancers in Chinese Patients. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065768
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065768