Multiple Factors Related to the Secretion of Glucagon-Like Peptide-1

Abstract EN

The glucagon-like peptide-1 is secreted by intestinal L cells in response to nutrient ingestion.

It regulates the secretion and sensitivity of insulin while suppressing glucagon secretion and decreasing postprandial glucose levels.

It also improves beta-cell proliferation and prevents beta-cell apoptosis induced by cytotoxic agents.

Additionally, glucagon-like peptide-1 delays gastric emptying and suppresses appetite.

The impaired secretion of glucagon-like peptide-1 has negative influence on diabetes, hyperlipidemia, and insulin resistance related diseases.

Thus, glucagon-like peptide-1-based therapies (glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors) are now well accepted in the management of type 2 diabetes.

The levels of glucagon-like peptide-1 are influenced by multiple factors including a variety of nutrients.

The component of a meal acts as potent stimulants of glucagon-like peptide-1 secretion.

The levels of its secretion change with the intake of different nutrients.

Some drugs also have influence on GLP-1 secretion.

Bariatric surgery may improve metabolism through the action on GLP-1 levels.

In recent years, there has been a great interest in developing effective methods to regulate glucagon-like peptide-1 secretion.

This review summarizes the literature on glucagon-like peptide-1 and related factors affecting its levels.