Sexual Absorption of Vaginal Progesterone: A Randomized Control Trial
Joint Authors
Matthews, Michelle L.
Usadi, Rebecca S.
Merriam, Kathryn S.
Leake, Kristina A.
Elliot, Mollie
Hurst, Bradley S.
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
To determine if sexual intercourse reduces absorption of vaginal progesterone gel in women and to determine if progesterone is absorbed by the male during intercourse.
Study Design.
Prospective, randomized, cross over, controlled study of 20 reproductive-aged women and their male sexual partners randomized to receive vaginal progesterone gel (Crinone 8% gel, Actavis Inc., USA) or placebo cream.
Serum progesterone for both male and female partners were measured 10 hours after intercourse.
One week later, subjects were crossed over to receive the opposite formulation.
In the third week, women used progesterone gel at night and abstained from intercourse.
Results.
Serum progesterone was significantly reduced with vaginal progesterone gel + intercourse compared with vaginal progesterone gel + abstinence ( P = 0.0075 ) .
Men absorbed significant progesterone during intercourse with a female partner using vaginal progesterone gel compared to placebo ( P = 0.0008 ) .
Conclusion(s).
Vaginal progesterone gel is reduced in women after intercourse which may decrease drug efficacy during luteal phase support.
Because men absorb low levels of progesterone during intercourse, exposure could cause adverse effects such as decreased libido.
This study is registered under Clinical Trial number NCT01959464.
American Psychological Association (APA)
Merriam, Kathryn S.& Leake, Kristina A.& Elliot, Mollie& Matthews, Michelle L.& Usadi, Rebecca S.& Hurst, Bradley S.. 2015. Sexual Absorption of Vaginal Progesterone: A Randomized Control Trial. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1065780
Modern Language Association (MLA)
Merriam, Kathryn S.…[et al.]. Sexual Absorption of Vaginal Progesterone: A Randomized Control Trial. International Journal of Endocrinology No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1065780
American Medical Association (AMA)
Merriam, Kathryn S.& Leake, Kristina A.& Elliot, Mollie& Matthews, Michelle L.& Usadi, Rebecca S.& Hurst, Bradley S.. Sexual Absorption of Vaginal Progesterone: A Randomized Control Trial. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1065780
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065780