Contribution to More Patient-Friendly ART Treatment: Efficacy of Continuous Low-Dose GnRH Agonist as the Only Luteal Support—Results of a Prospective, Randomized, Comparative Study
Joint Authors
Pirard, Céline
Loumaye, Ernest
Laurent, Pascale
Wyns, Christine
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
The aim of this pilot study was to evaluate intranasal buserelin for luteal phase support and compare its efficacy with standard vaginal progesterone in IVF/ICSI antagonist cycles.
Methods.
This is a prospective, randomized, open, parallel group study.
Forty patients underwent ovarian hyperstimulation with human menopausal gonadotropin under pituitary inhibition with gonadotropin-releasing hormone antagonist, while ovulation trigger and luteal support were achieved using intranasal GnRH agonist (group A).
Twenty patients had their cycle downregulated with buserelin and stimulated with hMG, while ovulation trigger was achieved using 10,000 IU human chorionic gonadotropin with luteal support by intravaginal progesterone (group B).
Results.
No difference was observed in estradiol levels.
Progesterone levels on day 5 were significantly lower in group A.
However, significantly higher levels of luteinizing hormone were observed in group A during the entire luteal phase.
Pregnancy rates (31.4% versus 22.2%), implantation rates (22% versus 15.4%), and clinical pregnancy rates (25.7% versus 16.7%) were not statistically different between groups, although a trend towards higher rates was observed in group A.
No luteal phase lasting less than 10 days was recorded in either group.
Conclusion.
Intranasal administration of buserelin is effective for providing luteal phase support in IVF/ICSI antagonist protocols.
American Psychological Association (APA)
Pirard, Céline& Loumaye, Ernest& Laurent, Pascale& Wyns, Christine. 2015. Contribution to More Patient-Friendly ART Treatment: Efficacy of Continuous Low-Dose GnRH Agonist as the Only Luteal Support—Results of a Prospective, Randomized, Comparative Study. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1065798
Modern Language Association (MLA)
Pirard, Céline…[et al.]. Contribution to More Patient-Friendly ART Treatment: Efficacy of Continuous Low-Dose GnRH Agonist as the Only Luteal Support—Results of a Prospective, Randomized, Comparative Study. International Journal of Endocrinology No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1065798
American Medical Association (AMA)
Pirard, Céline& Loumaye, Ernest& Laurent, Pascale& Wyns, Christine. Contribution to More Patient-Friendly ART Treatment: Efficacy of Continuous Low-Dose GnRH Agonist as the Only Luteal Support—Results of a Prospective, Randomized, Comparative Study. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1065798
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065798