Functional Diversity of Fibroblast Growth Factors in Bone Formation
Joint Authors
Takei, Yuichiro
Minamizaki, Tomoko
Yoshiko, Yuji
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The functional significance of fibroblast growth factor (FGF) signaling in bone formation has been demonstrated through genetic loss-of-function and gain-of-function approaches.
FGFs, comprising 22 family members, are classified into three subfamilies: canonical, hormone-like, and intracellular.
The former two subfamilies activate their signaling pathways through FGF receptors (FGFRs).
Currently, intracellular FGFs appear to be primarily involved in the nervous system.
Canonical FGFs such as FGF2 play significant roles in bone formation, and precise spatiotemporal control of FGFs and FGFRs at the transcriptional and posttranscriptional levels may allow for the functional diversity of FGFs during bone formation.
Recently, several research groups, including ours, have shown that FGF23, a member of the hormone-like FGF subfamily, is primarily expressed in osteocytes/osteoblasts.
This polypeptide decreases serum phosphate levels by inhibiting renal phosphate reabsorption and vitamin D3 activation, resulting in mineralization defects in the bone.
Thus, FGFs are involved in the positive and negative regulation of bone formation.
In this review, we focus on the reciprocal roles of FGFs in bone formation in relation to their local versus systemic effects.
American Psychological Association (APA)
Takei, Yuichiro& Minamizaki, Tomoko& Yoshiko, Yuji. 2015. Functional Diversity of Fibroblast Growth Factors in Bone Formation. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1065799
Modern Language Association (MLA)
Takei, Yuichiro…[et al.]. Functional Diversity of Fibroblast Growth Factors in Bone Formation. International Journal of Endocrinology No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1065799
American Medical Association (AMA)
Takei, Yuichiro& Minamizaki, Tomoko& Yoshiko, Yuji. Functional Diversity of Fibroblast Growth Factors in Bone Formation. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1065799
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065799