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Are Thyroid Hormone and Tumor Cell Proliferation in Human Breast Cancers Positive for HER2 Associated?
Joint Authors
Ardavanis, Alexandros
Tzovaras, Alexandros
Armonis, Basil
Skondra, Maria
Misitzis, John
Pectasides, Demetrios
Constantinos, Pantos
Mourouzis, Iordanis
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
This study investigated whether thyroid hormone (TH) levels are correlated to cell proliferation (Ki67), in euthyroid breast cancer patients.
Design and Methods.
86 newly diagnosed breast cancer patients with estrogen receptor (ER) positive tumors, who referred for surgery, were included in the study.
Results.
FT3, FT4, and TSH were within normal range.
No correlation was seen between Ki67 and FT3 (r=-0.17, P=0.15), FT4 (r=-0.13, P=0.25), or TSH (r=-0.10, P=0.39) in all patients studied.
However, subgroup analysis showed that, in HER2(+) patients, a negative correlation existed between FT3 levels and Ki67 (r=-0.60 and P=0.004) but not between Ki67 and FT4 (r=0.04 and P=0.85) or TSH (r=-0.23 and P=0.30).
In HER2(−) patients, there was no significant correlation between Ki67 and FT3 (r=-0.06, P=0.67), FT4 (r=-0.15, P=0.26), or TSH (r=-0.09, P=0.49).
Phospho-p44/total p44 ERK levels were found to be increased by 2-fold in HER2(+) versus HER2(−) tumors.
No difference was detected in phospho-p42/total p42 ERK levels.
Conclusions.
TH profile is not altered in patients with newly diagnosed breast cancer.
However, FT3 levels, even within normal range, are negatively correlated with cell proliferation in HER2(+) breast cancer tumors.
This response may be due to the interaction between ERK and TH signaling.
American Psychological Association (APA)
Mourouzis, Iordanis& Tzovaras, Alexandros& Armonis, Basil& Ardavanis, Alexandros& Skondra, Maria& Misitzis, John…[et al.]. 2015. Are Thyroid Hormone and Tumor Cell Proliferation in Human Breast Cancers Positive for HER2 Associated?. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1065809
Modern Language Association (MLA)
Mourouzis, Iordanis…[et al.]. Are Thyroid Hormone and Tumor Cell Proliferation in Human Breast Cancers Positive for HER2 Associated?. International Journal of Endocrinology No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1065809
American Medical Association (AMA)
Mourouzis, Iordanis& Tzovaras, Alexandros& Armonis, Basil& Ardavanis, Alexandros& Skondra, Maria& Misitzis, John…[et al.]. Are Thyroid Hormone and Tumor Cell Proliferation in Human Breast Cancers Positive for HER2 Associated?. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1065809
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065809