Liver Dysfunction Associated with Intravenous Methylprednisolone Pulse Therapy in Patients with Graves’ Orbitopathy
Joint Authors
Eguchi, Hiroyuki
Tani, Junichi
Hirao, Saori
Tsuruta, Munehisa
Tokubuchi, Ichiro
Yamada, Kentaro
Kasaoka, Masataka
Teshima, Yasuo
Kakuma, Tatsuyuki
Hiromatsu, Yuji
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Intravenous methylprednisolone (IVMP) pulse therapy is the first-line treatment for the active phase of moderate to severe Graves’ orbitopathy (GO).
However, acute and severe liver damage has been reported during and after IVMP therapy.
In this retrospective study, we investigated risk factors for liver dysfunction during and after IVMP therapy based on 175 Japanese patients with moderate to severe GO and treated at our center between 2003 and 2011.
The results showed that seven patients developed severe liver dysfunction with elevated serum alanine aminotransferase (ALT > 300 U/L).
Mild (40–100 U/L) and moderate (100–300 U/L) increases of ALT occurred in 62 patients (35%) and 10 patients (6%), respectively.
Liver dysfunction was more frequently observed in males, in patients receiving high-dose methylprednisolone, and patients aged over 50 years.
Preexistent viral hepatitis was significantly associated with liver dysfunction (65% in patients positive for hepatitis B core antibody and patients positive for hepatitis C virus antibodies).
Our study confirmed the association of liver dysfunction with IVMP during and after treatment.
It suggests that, in patients with GO, evaluation of preexisting risk factors—including viral hepatitis—and careful weekly monitoring of liver function during IVMP therapy and monthly thereafter for 12 months are warranted.
American Psychological Association (APA)
Eguchi, Hiroyuki& Tani, Junichi& Hirao, Saori& Tsuruta, Munehisa& Tokubuchi, Ichiro& Yamada, Kentaro…[et al.]. 2015. Liver Dysfunction Associated with Intravenous Methylprednisolone Pulse Therapy in Patients with Graves’ Orbitopathy. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1065825
Modern Language Association (MLA)
Eguchi, Hiroyuki…[et al.]. Liver Dysfunction Associated with Intravenous Methylprednisolone Pulse Therapy in Patients with Graves’ Orbitopathy. International Journal of Endocrinology No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1065825
American Medical Association (AMA)
Eguchi, Hiroyuki& Tani, Junichi& Hirao, Saori& Tsuruta, Munehisa& Tokubuchi, Ichiro& Yamada, Kentaro…[et al.]. Liver Dysfunction Associated with Intravenous Methylprednisolone Pulse Therapy in Patients with Graves’ Orbitopathy. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1065825
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065825