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Progesterone Upregulates Gene Expression in Normal Human Thyroid Follicular Cells
Joint Authors
Brum, llma Simoni
Hillebrand, Ana Caroline
Furlanetto, Tania Weber
Bertoni, Ana Paula Santin
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Thyroid cancer and thyroid nodules are more prevalent in women than men, so female sex hormones may have an etiological role in these conditions.
There are no data about direct effects of progesterone on thyroid cells, so the aim of the present study was to evaluate progesterone effects in the sodium-iodide symporter NIS, thyroglobulin TG, thyroperoxidase TPO, and KI-67 genes expression, in normal thyroid follicular cells, derived from human tissue.
NIS, TG, TPO, and KI-67 mRNA expression increased significantly after TSH 20 μUI/mL, respectively: 2.08 times, P<0.0001; 2.39 times, P=0.01; 1.58 times, P=0.0003; and 1.87 times, P<0.0001.
In thyroid cells treated with 20 μUI/mL TSH plus 10 nM progesterone, RNA expression of NIS, TG, and KI-67 genes increased, respectively: 1.78 times, P<0.0001; 1.75 times, P=0.037; and 1.95 times, P<0.0001, and TPO mRNA expression also increased, though not significantly (1.77 times, P=0.069).
These effects were abolished by mifepristone, an antagonist of progesterone receptor, suggesting that genes involved in thyroid cell function and proliferation are upregulated by progesterone.
This work provides evidence that progesterone has a direct effect on thyroid cells, upregulating genes involved in thyroid function and growth.
American Psychological Association (APA)
Bertoni, Ana Paula Santin& Brum, llma Simoni& Hillebrand, Ana Caroline& Furlanetto, Tania Weber. 2015. Progesterone Upregulates Gene Expression in Normal Human Thyroid Follicular Cells. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1065836
Modern Language Association (MLA)
Bertoni, Ana Paula Santin…[et al.]. Progesterone Upregulates Gene Expression in Normal Human Thyroid Follicular Cells. International Journal of Endocrinology No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1065836
American Medical Association (AMA)
Bertoni, Ana Paula Santin& Brum, llma Simoni& Hillebrand, Ana Caroline& Furlanetto, Tania Weber. Progesterone Upregulates Gene Expression in Normal Human Thyroid Follicular Cells. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1065836
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065836