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Decreased Expression of GPER1 Gene and Protein in Goiter
Joint Authors
Brum, llma Simoni
Weber, Raquel
Bessestil, Laura Walter
Furlanetto, Tania Weber
Bertoni, Ana Paula Santin
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Goiter is more common in women, suggesting that estrogen could be involved in its physiopathology.
The presence of classical estrogen receptors (ERα and ERβ) has been described in thyroid tissue, suggesting a direct effect of estrogen on the gland.
A nonclassic estrogen receptor, the G-protein-coupled estrogen receptor (GPER1), has been described recently in several tissues.
However, in goiter, the presence of this receptor has not been studied yet.
We investigated GPER1 gene and protein expressions in normal thyroid and goiter using reverse transcription quantitative polymerase chain reaction (RT-qPCR) and Western blot, respectively.
In normal thyroid (n=16) and goiter (n=19), GPER1 gene was expressed in all samples, while GPER1 protein was expressed in all samples of normal thyroid (n=15) but in only 72% of goiter samples (n=13).
When comparing GPER1 gene and protein levels in both conditions, gene expression and protein levels were higher in normal thyroid than in goiter, suggesting a role of this receptor in this condition.
Further studies are needed to elucidate the role of GPER1 in normal thyroid and goiter.
American Psychological Association (APA)
Weber, Raquel& Bertoni, Ana Paula Santin& Bessestil, Laura Walter& Brum, llma Simoni& Furlanetto, Tania Weber. 2015. Decreased Expression of GPER1 Gene and Protein in Goiter. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1065840
Modern Language Association (MLA)
Weber, Raquel…[et al.]. Decreased Expression of GPER1 Gene and Protein in Goiter. International Journal of Endocrinology No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1065840
American Medical Association (AMA)
Weber, Raquel& Bertoni, Ana Paula Santin& Bessestil, Laura Walter& Brum, llma Simoni& Furlanetto, Tania Weber. Decreased Expression of GPER1 Gene and Protein in Goiter. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1065840
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065840