Influence of Acarbose on Plasma Glucose Fluctuations in Insulin-Treated Patients with Type 2 Diabetes: A Pilot Study
Joint Authors
Li, Fengfei
Xu, Xiao-hua
Fu, Li-yuan
Su, Xiao-fei
Wu, Jin-dan
Lu, Chun-feng
Ye, Lei
Ma, Jian-hua
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-11
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background and Aims.
To evaluate the effect of adding acarbose on glycemic excursions measured by continuous glucose monitoring system (CGMS) in patients with type 2 diabetes mellitus (T2DM) already on insulin therapy.
Materials and Methods.
This was an opened and unblended study.
134 patients with T2DM were recruited.
After initial rapidly corrected hyperglycaemia by continuous subcutaneous insulin infusion (CSII) for 7 d, a 4–6-day premixed insulin titration period subsequently followed.
Patients were then randomized 1 : 1 to acarbose plus insulin group or insulin therapy group for 2 weeks.
CGMS was used to measure glucose fluctuations for at least 3 days after therapy cessation.
Results.
Patients in acarbose plus insulin group achieved a significant improvement of MAGE compared to that of insulin therapy only group ( 5.56 ± 2.16 versus 7.50 ± 3.28 mmol/L, P = 0.0 44 ), accompanied by a significant decrease in the incremental AUC of plasma glucose concentration above 10.0 mmol/L (0.5 [ 0.03 , 0.9 ] versus 0.85 [ 0.23,1.4 ] mmol/L per day, P = 0.037 ).
Conclusions.
Add-on acarbose to insulin therapy further improves glucose fluctuation in patients with T2DM.
This study was registered with ClinicalTrials.gov registration number ChiCTR-TRC-11001218.
American Psychological Association (APA)
Li, Fengfei& Xu, Xiao-hua& Fu, Li-yuan& Su, Xiao-fei& Wu, Jin-dan& Lu, Chun-feng…[et al.]. 2015. Influence of Acarbose on Plasma Glucose Fluctuations in Insulin-Treated Patients with Type 2 Diabetes: A Pilot Study. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1065850
Modern Language Association (MLA)
Li, Fengfei…[et al.]. Influence of Acarbose on Plasma Glucose Fluctuations in Insulin-Treated Patients with Type 2 Diabetes: A Pilot Study. International Journal of Endocrinology No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1065850
American Medical Association (AMA)
Li, Fengfei& Xu, Xiao-hua& Fu, Li-yuan& Su, Xiao-fei& Wu, Jin-dan& Lu, Chun-feng…[et al.]. Influence of Acarbose on Plasma Glucose Fluctuations in Insulin-Treated Patients with Type 2 Diabetes: A Pilot Study. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1065850
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065850