Hypothyroidism Affects Vascularization and Promotes Immune Cells Infiltration into Pancreatic Islets of Female Rabbits
Joint Authors
Rodríguez-Castelán, Julia
Martínez-Gómez, Margarita
Castelán, Francisco
Cuevas, Estela
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Thyroidectomy induces pancreatic edema and immune cells infiltration similarly to that observed in pancreatitis.
In spite of the controverted effects of hypothyroidism on serum glucose and insulin concentrations, the number and proliferation of Langerhans islet cells as well as the presence of extracellular matrix are affected depending on the islet size.
In this study, we evaluated the effect of methimazole-induced hypothyroidism on the vascularization and immune cells infiltration into islets.
A general observation of pancreas was also done.
Twelve Chinchilla-breed female adult rabbits were divided into control n=6 and hypothyroid groups (n=6, methimazole, 0.02% in drinking water for 30 days).
After the treatment, rabbits were sacrificed and their pancreas was excised, histologically processed, and stained with Periodic Acid-Schiff (PAS) or Masson’s Trichrome techniques.
Islets were arbitrarily classified into large, medium, and small ones.
The external and internal portions of each islet were also identified.
Student-t-test and Mann-Whitney-U test or two-way ANOVAs were used to compare variables between groups.
In comparison with control rabbits, hypothyroidism induced a strong infiltration of immune cells and a major presence of collagen and proteoglycans in the interlobular septa.
Large islets showed a high vascularization and immune cells infiltration.
The present results show that hypothyroidism induces pancreatitis and insulitis.
American Psychological Association (APA)
Rodríguez-Castelán, Julia& Martínez-Gómez, Margarita& Castelán, Francisco& Cuevas, Estela. 2015. Hypothyroidism Affects Vascularization and Promotes Immune Cells Infiltration into Pancreatic Islets of Female Rabbits. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065875
Modern Language Association (MLA)
Rodríguez-Castelán, Julia…[et al.]. Hypothyroidism Affects Vascularization and Promotes Immune Cells Infiltration into Pancreatic Islets of Female Rabbits. International Journal of Endocrinology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1065875
American Medical Association (AMA)
Rodríguez-Castelán, Julia& Martínez-Gómez, Margarita& Castelán, Francisco& Cuevas, Estela. Hypothyroidism Affects Vascularization and Promotes Immune Cells Infiltration into Pancreatic Islets of Female Rabbits. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065875
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065875