Decreased Insulin Sensitivity and Impaired Fibrinolytic Activity in Type 2 Diabetes Patients and Nondiabetics with Ischemic Stroke
Joint Authors
Civcic, Milorad
Kostic, Vladimir S.
Aleksic, Sandra
Milicic, Tanja
Covickovic Sternic, Nadezda
Jeremic, Veljko
Rajkovic, Natasa
Stanarcic, Jelena
Lalic, Katarina
Macesic, Marija
Jotic, Aleksandra
Lalic, Nebojsa M.
Seferovic, Jelena P.
Mijajlovic, Milija
Lukic, Ljiljana
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We analyzed (a) insulin sensitivity (IS), (b) plasma insulin (PI), and (c) plasminogen activator inhibitor-1 (PAI-1) in type 2 diabetes (T2D) patients with (group A) and without (group B) atherothrombotic ischemic stroke (ATIS), nondiabetics with ATIS (group C), and healthy controls (group D).
IS was determined by minimal model (Si).
Si was lower in A versus B ( 1.18 ± 0.67 versus 2.82 ± 0.61 min−1/mU/L × 104; P < 0.001 ) and in C versus D ( 3.18 ± 0.93 versus 6.13 ± 1.69 min−1/mU/L × 104; P < 0.001 ).
PI and PAI-1 were higher in A versus B (PI: 19.61 ± 4.08 versus 14.91 ± 1.66 mU/L; P < 0.001 , PAI-1: 7.75 ± 1.04 versus 4.57 ± 0.72 mU/L; P < 0.001 ) and in C versus D (PI: 15.14 ± 2.20 versus 7.58 ± 2.05 mU/L; P < 0.001 , PAI-1: 4.78 ± 0.98 versus 3.49 ± 1.04 mU/L; P < 0.001 ).
Si correlated with PAI-1 in T2D patients and nondiabetics, albeit stronger in T2D.
Binary logistic regression identified insulin, PAI-1, and Si as independent predictors for ATIS in T2D patients and nondiabetics.
The results imply that insulin resistance and fasting hyperinsulinemia might exert their atherogenic impact through the impaired fibrinolysis.
American Psychological Association (APA)
Jotic, Aleksandra& Milicic, Tanja& Covickovic Sternic, Nadezda& Kostic, Vladimir S.& Lalic, Katarina& Jeremic, Veljko…[et al.]. 2015. Decreased Insulin Sensitivity and Impaired Fibrinolytic Activity in Type 2 Diabetes Patients and Nondiabetics with Ischemic Stroke. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065894
Modern Language Association (MLA)
Jotic, Aleksandra…[et al.]. Decreased Insulin Sensitivity and Impaired Fibrinolytic Activity in Type 2 Diabetes Patients and Nondiabetics with Ischemic Stroke. International Journal of Endocrinology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1065894
American Medical Association (AMA)
Jotic, Aleksandra& Milicic, Tanja& Covickovic Sternic, Nadezda& Kostic, Vladimir S.& Lalic, Katarina& Jeremic, Veljko…[et al.]. Decreased Insulin Sensitivity and Impaired Fibrinolytic Activity in Type 2 Diabetes Patients and Nondiabetics with Ischemic Stroke. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065894
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065894