Mechanisms of Normalisation of Bone Metabolism during Recovery from Hyperthyroidism: Potential Role for Sclerostin and Parathyroid Hormone
Joint Authors
Skowrońska-Jóźwiak, Elżbieta
Lewandowski, Krzysztof C.
Adamczewski, Zbigniew
Krawczyk-Rusiecka, Kinga
Lewiński, Andrzej
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-23
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Sclerostin, a protein expressed by osteocytes, is a negative regulator of bone formation.
The aim of the study was to investigate the relationship between parathyroid hormone (PTH) and markers of bone metabolism and changes of sclerostin concentrations before and after treatment of hyperthyroidism.
Patients and Methods.
The study involved 33 patients (26 women), age (mean ± SD) 48 ± 15 years, with hyperthyroidism.
Serum sclerostin, PTH, calcium, and bone markers [osteocalcin (OC) and collagen type I cross-linked C-telopeptide I (CTX)] were measured at diagnosis of hyperthyroidism and after treatment with thiamazole.
Results.
After treatment of hyperthyroidism a significant decrease in free T3 (FT3) and free T4 (FT4) concentrations was accompanied by marked decrease of serum sclerostin (from 43.7 ± 29.3 to 28.1 ± 18.4 pmol/L; p < 0.001 ), OC (from 35.6 ± 22.0 to 27.0 ± 14.3 ng/mL; p < 0.001 ), and CTX (from 0.49 ± 0.35 to 0.35 ± 0.23 ng/dL; p < 0.005 ), accompanied by an increase of PTH (from 29.3 ± 14.9 to 39.8 ± 19.8; p < 0.001 ).
During hyperthyroidism there was a positive correlation between sclerostin and CTX ( r s = 0.41 , p < 0.05 ) and between OC and thyroid hormones (with FT3 r s = 0.42 , with FT4 r s = 0.45 , p < 0.05 ).
Conclusions.
Successful treatment of hyperthyroidism results in a significant decrease in serum sclerostin and bone markers concentrations, accompanied by an increase of PTH.
American Psychological Association (APA)
Skowrońska-Jóźwiak, Elżbieta& Lewandowski, Krzysztof C.& Adamczewski, Zbigniew& Krawczyk-Rusiecka, Kinga& Lewiński, Andrzej. 2015. Mechanisms of Normalisation of Bone Metabolism during Recovery from Hyperthyroidism: Potential Role for Sclerostin and Parathyroid Hormone. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1065899
Modern Language Association (MLA)
Skowrońska-Jóźwiak, Elżbieta…[et al.]. Mechanisms of Normalisation of Bone Metabolism during Recovery from Hyperthyroidism: Potential Role for Sclerostin and Parathyroid Hormone. International Journal of Endocrinology No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1065899
American Medical Association (AMA)
Skowrońska-Jóźwiak, Elżbieta& Lewandowski, Krzysztof C.& Adamczewski, Zbigniew& Krawczyk-Rusiecka, Kinga& Lewiński, Andrzej. Mechanisms of Normalisation of Bone Metabolism during Recovery from Hyperthyroidism: Potential Role for Sclerostin and Parathyroid Hormone. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1065899
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065899