Sitagliptin: Is It Effective in Routine Clinical Practice?
Joint Authors
Mohan Dallumal, Rita
Chua, Siew Siang
Wu, David Bin-Chia
Vethakkan, Shireene Ratna
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aim.
The present study was conducted to determine the glycaemic effects of sitagliptin in type 2 diabetes patients.
Methods.
Data was collected from patient medical records of a major teaching hospital in Malaysia, from 2009 to 2012.
Glycated hemoglobin (HbA1c) values prior to and up to 12 months after the initiation of sitagliptin were analysed.
The change in HbA1c values was accounted for based on a generalized linear model generated using the Generalized Estimating Equations (GEE) method.
Results and Discussion.
Of the 457 patients, 53.6% were elderly and 81.4% were overweight.
The mean HbA1c (standard deviation) before initiation of sitagliptin was 8.5 (1.4)%.
This dropped to 7.7 (1.4)%, 3 to 6 months after initiation of sitagliptin, with a mean difference of 0.8% (95% confidence interval (CI): 0.7–1.0; P<0.001).
However, this value increased to 8.0 (1.7)% after 7 to 12 months on sitagliptin (P=0.002) with a mean difference from baseline of 0.6% (95% CI: 0.4–0.7; P < 0.001).
Conclusion.
In routine clinical practice, sitagliptin produces a significant reduction in mean HbA1c (0.8%) within the first 6 months of use which corresponds to efficacy data obtained in controlled clinical trials.
However, this reduction was lesser, 7 to 12 month later.
American Psychological Association (APA)
Mohan Dallumal, Rita& Chua, Siew Siang& Wu, David Bin-Chia& Vethakkan, Shireene Ratna. 2015. Sitagliptin: Is It Effective in Routine Clinical Practice?. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1065903
Modern Language Association (MLA)
Mohan Dallumal, Rita…[et al.]. Sitagliptin: Is It Effective in Routine Clinical Practice?. International Journal of Endocrinology No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1065903
American Medical Association (AMA)
Mohan Dallumal, Rita& Chua, Siew Siang& Wu, David Bin-Chia& Vethakkan, Shireene Ratna. Sitagliptin: Is It Effective in Routine Clinical Practice?. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1065903
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065903