Bone Regulates Glucose Metabolism as an Endocrine Organ through Osteocalcin
Joint Authors
Shao, Jin
Wang, Zhi
Yang, Tieyi
Ying, Hui
Zhang, Yan
Liu, Shuyi
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Skeleton was considered as a dynamic connective tissue, which was essential for mobility, calcium homeostasis, and hematopoietic niche.
However more and more evidences indicate that skeleton works not only as a structural scaffold but also as an endocrine organ, which regulates several metabolic processes.
Besides osteoprotegerin (OPG), sclerostin (SOST), and Dickopf (DKK) which play essential roles in bone formation, modelling, remodelling, and homeostasis, bone can also secret hormones, such as osteocalcin (OCN), which promotes proliferation of β cells, insulin secretion, and insulin sensitivity.
Additionally OCN can also regulate the fat cells and male gonad endocrine activity and be regulated by insulin and the neural system.
In summary, skeleton has endocrine function via OCN and plays an important role in energy metabolism, especially in glucose metabolism.
American Psychological Association (APA)
Shao, Jin& Wang, Zhi& Yang, Tieyi& Ying, Hui& Zhang, Yan& Liu, Shuyi. 2015. Bone Regulates Glucose Metabolism as an Endocrine Organ through Osteocalcin. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1065907
Modern Language Association (MLA)
Shao, Jin…[et al.]. Bone Regulates Glucose Metabolism as an Endocrine Organ through Osteocalcin. International Journal of Endocrinology No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1065907
American Medical Association (AMA)
Shao, Jin& Wang, Zhi& Yang, Tieyi& Ying, Hui& Zhang, Yan& Liu, Shuyi. Bone Regulates Glucose Metabolism as an Endocrine Organ through Osteocalcin. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1065907
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065907