Myocardial Infarction and Stroke Risk in Young Healthy Men Treated with Injectable Testosterone
Joint Authors
Tan, Robert S.
Cook, Kelly R.
Reilly, William G.
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This study was conducted to examine the association between testosterone therapy and new myocardial infarction (MI) and stroke events in a series of patients treated at Low T Centers across the United States, consisting of mainly young (mean age = 46), otherwise, healthy men.
Electronic medical records were queried between the years 2009 and 2014 to identify patients diagnosed with hypogonadism, MI, and stroke, as indicated by ICD-9 codes.
The incidence of MI and stroke events was compared to community-based registries.
39,936 patients recruited from 40 Low T Centers across the United States were treated and 19,968 met eligibility criteria for receiving testosterone treatment.
The incidence rate ratio (IRR) for MI in testosterone- (T-) treated versus nontreated patients was 0.14 (C.I.
= 0.08 to 0.18, P<0.0001) whereas the IRR for stroke for T-treated versus nontreated patients was 0.11 (C.I.
= 0.02 to 0.13, P<0.0001).
There was no evidence of worsening preexisting MI or stroke in patients treated with testosterone.
The experience in Low T Centers shows that, in an injectable testosterone patient registry, testosterone is generally safe for younger men who do not have significant risk factors.
Of patients that developed MI with testosterone, there was no association with testosterone or hematocrit levels.
American Psychological Association (APA)
Tan, Robert S.& Cook, Kelly R.& Reilly, William G.. 2015. Myocardial Infarction and Stroke Risk in Young Healthy Men Treated with Injectable Testosterone. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065911
Modern Language Association (MLA)
Tan, Robert S.…[et al.]. Myocardial Infarction and Stroke Risk in Young Healthy Men Treated with Injectable Testosterone. International Journal of Endocrinology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1065911
American Medical Association (AMA)
Tan, Robert S.& Cook, Kelly R.& Reilly, William G.. Myocardial Infarction and Stroke Risk in Young Healthy Men Treated with Injectable Testosterone. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065911
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065911