Synergy between HDAC and PARP Inhibitors on Proliferation of a Human Anaplastic Thyroid Cancer-Derived Cell Line
Joint Authors
Damante, Giuseppe
Russo, Diego
Baldan, Federica
Mio, Catia
Allegri, Lorenzo
Puppin, Cinzia
Filetti, Sebastiano
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Anaplastic thyroid carcinoma (ATC) is a very aggressive human malignancy, having a marked degree of invasiveness and no features of thyroid differentiation.
It is known that either HDAC inhibitors or PARP inhibitors have antiproliferative effects on thyroid cancer cells.
Therefore, in this study the possible synergy between the two types of compounds has been investigated.
The ATC-derived cell line SW1736 has been treated with the HDAC inhibitor suberoylanilide hydroxamic acid (SAHA) and the PARP inhibitor PJ34, alone or in combination.
In terms of cell viability, the combination index value was always lower than 1 at various tested dosages, indicating, therefore, synergy in a wide range of doses for both compounds.
Synergy was also observed in induction of apoptosis.
In terms of thyroid-specific gene expression, synergy was observed for TSHR mRNA levels but not for NIS, TTF1, TTF2, and PAX8 mRNA levels.
Altogether, these data suggest that the combined use of HDAC and PARP inhibitors may be a useful strategy for treatment of ATC.
American Psychological Association (APA)
Baldan, Federica& Mio, Catia& Allegri, Lorenzo& Puppin, Cinzia& Russo, Diego& Filetti, Sebastiano…[et al.]. 2015. Synergy between HDAC and PARP Inhibitors on Proliferation of a Human Anaplastic Thyroid Cancer-Derived Cell Line. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065913
Modern Language Association (MLA)
Baldan, Federica…[et al.]. Synergy between HDAC and PARP Inhibitors on Proliferation of a Human Anaplastic Thyroid Cancer-Derived Cell Line. International Journal of Endocrinology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1065913
American Medical Association (AMA)
Baldan, Federica& Mio, Catia& Allegri, Lorenzo& Puppin, Cinzia& Russo, Diego& Filetti, Sebastiano…[et al.]. Synergy between HDAC and PARP Inhibitors on Proliferation of a Human Anaplastic Thyroid Cancer-Derived Cell Line. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065913
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065913