Polymorphisms of Leptin (-2548 GA) and Leptin Receptor (Q223R) Genes in Iranian Women with Breast Cancer
Joint Authors
Mahmoudi, Reza
Noori Alavicheh, Bahareh
Nazer Mozaffari, Mohammad Amin
Fararouei, Mohammad
Nikseresht, Mohsen
Source
International Journal of Genomics
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Recent studies have shown that polymorphisms in leptin and leptin receptor genes are associated with increased risk for breast cancer.
This study aimed at investigating -2548 G/A polymorphism in leptin gene and Q223R polymorphism in leptin receptor gene in patients with breast cancer.
The study included 45 women with breast cancer and 41 healthy women.
PCR-RFLP was used to determine the genotype of the subjects in terms of -2548 G/A polymorphism in leptin gene and Q223R polymorphism in leptin receptor gene.
Serum levels of leptin were also measured by ELISA.
For -2548 G/A polymorphism, the genotypes were homozygous AA (OR = 1.13; p=0.8) and heterozygous GA (OR = 0.41; p=0.2) and for Q223R polymorphism, the genotypes were homozygous RR (OR = 6.7; p=0.09) and heterozygous QR (OR = 8.3; p=0.06).
The mean serum level of leptin was 33.22 ± 21.35 ng/mL in patients and 29.49 ± 23.27 ng/mL in the normal participants (p=0.3).
Although, despite the magnitude of the associations, the results suggested no statistically significant contribution of -2548 G/A polymorphism (in leptin gene), Q223R polymorphism (in leptin receptor gene), and serum leptin levels in predicting the risk of breast cancer, further studies with larger sample size are suggested.
American Psychological Association (APA)
Mahmoudi, Reza& Noori Alavicheh, Bahareh& Nazer Mozaffari, Mohammad Amin& Fararouei, Mohammad& Nikseresht, Mohsen. 2015. Polymorphisms of Leptin (-2548 GA) and Leptin Receptor (Q223R) Genes in Iranian Women with Breast Cancer. International Journal of Genomics،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1065989
Modern Language Association (MLA)
Mahmoudi, Reza…[et al.]. Polymorphisms of Leptin (-2548 GA) and Leptin Receptor (Q223R) Genes in Iranian Women with Breast Cancer. International Journal of Genomics No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1065989
American Medical Association (AMA)
Mahmoudi, Reza& Noori Alavicheh, Bahareh& Nazer Mozaffari, Mohammad Amin& Fararouei, Mohammad& Nikseresht, Mohsen. Polymorphisms of Leptin (-2548 GA) and Leptin Receptor (Q223R) Genes in Iranian Women with Breast Cancer. International Journal of Genomics. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1065989
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065989