Exploring the Functional Disorder and Corresponding Key Transcription Factors in Intraductal Papillary Mucinous Neoplasms Progression
Joint Authors
Gao, Ying-tang
Bai, Guiying
Wu, Chenxuan
Shu, Guiming
Source
International Journal of Genomics
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This study has analyzed the gene expression patterns of an IPMN microarray dataset including normal pancreatic ductal tissue (NT), intraductal papillary mucinous adenoma (IPMA), intraductal papillary mucinous carcinoma (IPMC), and invasive ductal carcinoma (IDC) samples.
And eight clusters of differentially expressed genes (DEGs) with similar expression pattern were detected by k-means clustering.
Then a survey map of functional disorder in IPMN progression was established by functional enrichment analysis of these clusters.
In addition, transcription factors (TFs) enrichment analysis was used to detect the key TFs in each cluster of DEGs, and three TFs (FLI1, ERG, and ESR1) were found to significantly regulate DEGs in cluster 1, and expression of these three TFs was validated by qRT-PCR.
All these results indicated that these three TFs might play key roles in the early stages of IPMN progression.
American Psychological Association (APA)
Bai, Guiying& Wu, Chenxuan& Gao, Ying-tang& Shu, Guiming. 2015. Exploring the Functional Disorder and Corresponding Key Transcription Factors in Intraductal Papillary Mucinous Neoplasms Progression. International Journal of Genomics،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1065995
Modern Language Association (MLA)
Bai, Guiying…[et al.]. Exploring the Functional Disorder and Corresponding Key Transcription Factors in Intraductal Papillary Mucinous Neoplasms Progression. International Journal of Genomics No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1065995
American Medical Association (AMA)
Bai, Guiying& Wu, Chenxuan& Gao, Ying-tang& Shu, Guiming. Exploring the Functional Disorder and Corresponding Key Transcription Factors in Intraductal Papillary Mucinous Neoplasms Progression. International Journal of Genomics. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1065995
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065995