Phylogenomic and Molecular Demarcation of the Core Members of the Polyphyletic Pasteurellaceae Genera Actinobacillus, Haemophilus, and Pasteurella
Joint Authors
Naushad, Sohail
Adeolu, Mobolaji
Goel, Nisha
Khadka, Bijendra
Al-Dahwi, Aqeel
Gupta, Radhey S.
Source
International Journal of Genomics
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-03
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The genera Actinobacillus, Haemophilus, and Pasteurella exhibit extensive polyphyletic branching in phylogenetic trees and do not represent coherent clusters of species.
In this study, we have utilized molecular signatures identified through comparative genomic analyses in conjunction with genome based and multilocus sequence based phylogenetic analyses to clarify the phylogenetic and taxonomic boundary of these genera.
We have identified large clusters of Actinobacillus, Haemophilus, and Pasteurella species which represent the “sensu stricto” members of these genera.
We have identified 3, 7, and 6 conserved signature indels (CSIs), which are specifically shared by sensu stricto members of Actinobacillus, Haemophilus, and Pasteurella, respectively.
We have also identified two different sets of CSIs that are unique characteristics of the pathogen containing genera Aggregatibacter and Mannheimia, respectively.
It is now possible to demarcate the genera Actinobacillus sensu stricto, Haemophilus sensu stricto, and Pasteurella sensu stricto on the basis of discrete molecular signatures.
The other members of the genera Actinobacillus, Haemophilus, and Pasteurella that do not fall within the “sensu stricto” clades and do not contain these molecular signatures should be reclassified as other genera.
The CSIs identified here also provide useful diagnostic targets for the identification of current and novel members of the indicated genera.
American Psychological Association (APA)
Naushad, Sohail& Adeolu, Mobolaji& Goel, Nisha& Khadka, Bijendra& Al-Dahwi, Aqeel& Gupta, Radhey S.. 2015. Phylogenomic and Molecular Demarcation of the Core Members of the Polyphyletic Pasteurellaceae Genera Actinobacillus, Haemophilus, and Pasteurella. International Journal of Genomics،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1065997
Modern Language Association (MLA)
Naushad, Sohail…[et al.]. Phylogenomic and Molecular Demarcation of the Core Members of the Polyphyletic Pasteurellaceae Genera Actinobacillus, Haemophilus, and Pasteurella. International Journal of Genomics No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1065997
American Medical Association (AMA)
Naushad, Sohail& Adeolu, Mobolaji& Goel, Nisha& Khadka, Bijendra& Al-Dahwi, Aqeel& Gupta, Radhey S.. Phylogenomic and Molecular Demarcation of the Core Members of the Polyphyletic Pasteurellaceae Genera Actinobacillus, Haemophilus, and Pasteurella. International Journal of Genomics. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1065997
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065997