Helicobacter pylori: Genomic Insight into the Host-Pathogen Interaction
Joint Authors
Haley, Kathryn P.
Gaddy, Jennifer A.
Source
International Journal of Genomics
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The advent of genomic analyses has revolutionized the study of human health.
Infectious disease research in particular has experienced an explosion of bacterial genomic, transcriptomic, and proteomic data complementing the phenotypic methods employed in traditional bacteriology.
Together, these techniques have revealed novel virulence determinants in numerous pathogens and have provided information for potential chemotherapeutics.
The bacterial pathogen, Helicobacter pylori, has been recognized as a class 1 carcinogen and contributes to chronic inflammation within the gastric niche.
Genomic analyses have uncovered remarkable coevolution between the human host and H.
pylori.
Perturbation of this coevolution results in dysregulation of the host-pathogen interaction, leading to oncogenic effects.
This review discusses the relationship of H.
pylori with the human host and environment and the contribution of each of these factors to disease progression, with an emphasis on features that have been illuminated by genomic tools.
American Psychological Association (APA)
Haley, Kathryn P.& Gaddy, Jennifer A.. 2015. Helicobacter pylori: Genomic Insight into the Host-Pathogen Interaction. International Journal of Genomics،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1066012
Modern Language Association (MLA)
Haley, Kathryn P.& Gaddy, Jennifer A.. Helicobacter pylori: Genomic Insight into the Host-Pathogen Interaction. International Journal of Genomics No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1066012
American Medical Association (AMA)
Haley, Kathryn P.& Gaddy, Jennifer A.. Helicobacter pylori: Genomic Insight into the Host-Pathogen Interaction. International Journal of Genomics. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1066012
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1066012