Genetic Background Modulates lncRNA-Coordinated Tissue Response to Low Dose Ionizing Radiation
Joint Authors
Tang, Jonathan
Huang, Yurong
Nguyen, David H.
Costes, Sylvain V.
Snijders, Antoine M.
Mao, Jian-Hua
Source
International Journal of Genomics
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Long noncoding RNAs (lncRNAs) are emerging as key regulators of diverse cell functions and processes.
However, the relevance of lncRNAs in the cell and tissue response to ionizing radiation has not yet been characterized.
Here we used microarray profiling to determine lncRNA and mRNA expression in mammary glands of BALB/c and SPRET/EiJ mice after low-dose ionizing radiation (LDIR) exposure.
We found that unirradiated mammary tissues of these strains differed significantly in baseline expressions of 290 lncRNAs.
LDIR exposure (10 cGy) induced a significant change in the expression of many lncRNAs.
The vast majority of lncRNAs identified to be differentially expressed after LDIR in either BALB/c or SPRET/EiJ had a significantly correlated expression pattern with at least one LDIR responsive mRNA.
Functional analysis revealed that the response to LDIR in BALB/c mice is highly dynamic with enrichment for genes involved in tissue injury, inflammatory responses, and mammary gland development at 2, 4, and 8 weeks after LDIR, respectively.
Our study demonstrates that genetic background strongly influences the expression of lncRNAs and their response to radiation and that lncRNAs may coordinate the tissue response to LDIR exposure via regulation of coding mRNAs.
American Psychological Association (APA)
Tang, Jonathan& Huang, Yurong& Nguyen, David H.& Costes, Sylvain V.& Snijders, Antoine M.& Mao, Jian-Hua. 2015. Genetic Background Modulates lncRNA-Coordinated Tissue Response to Low Dose Ionizing Radiation. International Journal of Genomics،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1066018
Modern Language Association (MLA)
Tang, Jonathan…[et al.]. Genetic Background Modulates lncRNA-Coordinated Tissue Response to Low Dose Ionizing Radiation. International Journal of Genomics No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1066018
American Medical Association (AMA)
Tang, Jonathan& Huang, Yurong& Nguyen, David H.& Costes, Sylvain V.& Snijders, Antoine M.& Mao, Jian-Hua. Genetic Background Modulates lncRNA-Coordinated Tissue Response to Low Dose Ionizing Radiation. International Journal of Genomics. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1066018
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1066018