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Blood Pressure Response to Zofenopril or Irbesartan Each Combined with Hydrochlorothiazide in High-Risk Hypertensives Uncontrolled by Monotherapy: A Randomized, Double-Blind, Controlled, Parallel Group, Noninferiority Trial
Joint Authors
Malacco, Ettore
Omboni, Stefano
Parati, Gianfranco
Source
International Journal of Hypertension
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-05
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
In this randomized, double-blind, controlled, parallel group study (ZENITH), 434 essential hypertensives with additional cardiovascular risk factors, uncontrolled by a previous monotherapy, were treated for 18 weeks with zofenopril 30 or 60 mg plus hydrochlorothiazide (HCTZ) 12.5 mg or irbesartan 150 or 300 mg plus HCTZ.
Rate of office blood pressure (BP) response (zofenopril: 68% versus irbesartan: 70%; p = 0.778 ) and 24-hour BP response (zofenopril: 85% versus irbesartan: 84%; p = 0.781 ) was similar between the two treatment groups.
Cardiac and renal damage was equally reduced by both treatments, whereas the rate of carotid plaque regression was significantly larger with zofenopril.
In conclusion, uncontrolled monotherapy treated hypertensives effectively respond to a combination of zofenopril or irbesartan plus a thiazide diuretic, in terms of either BP response or target organ damage progression.
American Psychological Association (APA)
Malacco, Ettore& Omboni, Stefano& Parati, Gianfranco. 2015. Blood Pressure Response to Zofenopril or Irbesartan Each Combined with Hydrochlorothiazide in High-Risk Hypertensives Uncontrolled by Monotherapy: A Randomized, Double-Blind, Controlled, Parallel Group, Noninferiority Trial. International Journal of Hypertension،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1066101
Modern Language Association (MLA)
Malacco, Ettore…[et al.]. Blood Pressure Response to Zofenopril or Irbesartan Each Combined with Hydrochlorothiazide in High-Risk Hypertensives Uncontrolled by Monotherapy: A Randomized, Double-Blind, Controlled, Parallel Group, Noninferiority Trial. International Journal of Hypertension No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1066101
American Medical Association (AMA)
Malacco, Ettore& Omboni, Stefano& Parati, Gianfranco. Blood Pressure Response to Zofenopril or Irbesartan Each Combined with Hydrochlorothiazide in High-Risk Hypertensives Uncontrolled by Monotherapy: A Randomized, Double-Blind, Controlled, Parallel Group, Noninferiority Trial. International Journal of Hypertension. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1066101
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1066101