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Genetic Variant of C-5434T REN Enhancer on Serum Renin Levels and Binding Pattern of Signal Transducers and Activators Transcription 3
Joint Authors
Maslahah, Imama
Rohman, Mohammad Saifur
Widodo, Nashi
Endharti, Agustina Tri
Utomo, Didik
Source
International Journal of Hypertension
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-21
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The human renin gene has been widely known to be involved in essential hypertension (EH) pathogenesis.
Genetic variant C-5434T of REN enhancer contributed to renin gene transcription and serum renin regulation.
However, the mechanism associated with the transcription level changes remains unknown, and only a few reports exist that discussed serum renin levels on C-5434T of REN.
Thus, this study aims to investigate the relationship between genetic variant C-5434T of REN enhancer and serum renin levels in Indonesian hypertensive patients.
SNP of C-5434T was genotyped in 56 hypertensive patients by using RFLP.
The data showed that serum renin is slightly higher in hypertensive patients with the TT genotype (39 ± 10.3) than patients with the CC genotype (33 ± 10.6) but the difference was not statistically significant (p=0.35).
Here, we also present a docking approach for predicting interaction between genetic variant -5434C/T and STAT3 (Signal Transducers and Activators Transcription 3), the predicted transcription factor that regulates renin gene enhancer.
The results showed that STAT3-DNA allele T more favorably binds to DNA than STAT3-DNA allele C.
These data suggest that the presence of genetic variant C-5434T has changed the binding pattern of STAT3 to REN enhancer.
This is likely to influence STAT3 activity to stimulate the expression of renin gene in producing renin.
American Psychological Association (APA)
Maslahah, Imama& Rohman, Mohammad Saifur& Widodo, Nashi& Endharti, Agustina Tri& Utomo, Didik. 2015. Genetic Variant of C-5434T REN Enhancer on Serum Renin Levels and Binding Pattern of Signal Transducers and Activators Transcription 3. International Journal of Hypertension،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1066115
Modern Language Association (MLA)
Maslahah, Imama…[et al.]. Genetic Variant of C-5434T REN Enhancer on Serum Renin Levels and Binding Pattern of Signal Transducers and Activators Transcription 3. International Journal of Hypertension No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1066115
American Medical Association (AMA)
Maslahah, Imama& Rohman, Mohammad Saifur& Widodo, Nashi& Endharti, Agustina Tri& Utomo, Didik. Genetic Variant of C-5434T REN Enhancer on Serum Renin Levels and Binding Pattern of Signal Transducers and Activators Transcription 3. International Journal of Hypertension. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1066115
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1066115