Brain Angiotensin II Type 1 Receptor Blockade Improves Dairy Blood Pressure Variability via Sympathoinhibition in Hypertensive Rats
Joint Authors
Hirooka, Yoshitaka
Sunagawa, Kenji
Kishi, Takuya
Source
International Journal of Hypertension
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Abnormal blood pressure (BP) elevation in early morning is known to cause cardiovascular events.
Previous studies have suggested that one of the reasons in abnormal dairy BP variability is sympathoexcitation.
We have demonstrated that brain angiotensin II type 1 receptor (AT1R) causes sympathoexcitation.
The aim of the present study was to investigate whether central AT1R blockade attenuates the excess BP elevation in rest-to-active phase in hypertensive rats or not.
Stroke-prone spontaneously hypertensive rats (SHRSP) were treated with intracerebroventricular infusion (ICV) of AT1R receptor blocker (ARB), oral administration of hydralazine (HYD), or ICV of vehicle (VEH).
Telemetric averaged mean BP (MBP) was measured at early morning (EM), after morning (AM), and night (NT).
At EM, MBP was significantly lower in ARB to a greater extent than in HYD compared to VEH, though MBP at AM was the same in ARB and HYD.
At NT, MBP was also significantly lower in ARB than in HYD.
These results in MBP were compatible to those in sympathoexcitation and suggest that central AT1R blockade attenuates excess BP elevation in early active phase and continuous BP elevation during rest phase independent of depressor response in hypertensive rats.
American Psychological Association (APA)
Kishi, Takuya& Hirooka, Yoshitaka& Sunagawa, Kenji. 2015. Brain Angiotensin II Type 1 Receptor Blockade Improves Dairy Blood Pressure Variability via Sympathoinhibition in Hypertensive Rats. International Journal of Hypertension،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1066129
Modern Language Association (MLA)
Kishi, Takuya…[et al.]. Brain Angiotensin II Type 1 Receptor Blockade Improves Dairy Blood Pressure Variability via Sympathoinhibition in Hypertensive Rats. International Journal of Hypertension No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1066129
American Medical Association (AMA)
Kishi, Takuya& Hirooka, Yoshitaka& Sunagawa, Kenji. Brain Angiotensin II Type 1 Receptor Blockade Improves Dairy Blood Pressure Variability via Sympathoinhibition in Hypertensive Rats. International Journal of Hypertension. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1066129
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1066129