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VEGFR-2 Expression in Glioblastoma Multiforme Depends on Inflammatory Tumor Microenvironment
Joint Authors
Jaal, Jana
Jõgi, Tõnu
Kase, Marju
Minajeva, Ave
Saretok, Mikk
Adamson, Aidi
Junninen, Jelizaveta
Metsaots, Tõnis
Joonsalu, Madis
Vardja, Markus
Asser, Toomas
Source
International Journal of Inflammation
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Glioblastoma multiforme (GBM) is one of the most angiogenic tumors.
However, antiangiogenic therapy has not shown significant clinical efficacy.
The aim of our study was to evaluate the impact of inflammatory tumor microenvironment on the expression of vascular endothelial growth factor receptor 2 (VEGFR-2).
Surgically excised primary GBM tissues were histologically examined for overall extent of inflammation (score 1–3).
After immunohistochemistry, the tissue expression of ICAM-1 (optical density), the number of VEGFR-2 positive (VEGFR-2+) blood vessels (per microscopic field), and the endothelial staining intensity of VEGFR-2 (score 0–3) were determined.
In GBM, the extent of inflammation was 1.9 ± 0.7 (group mean ± SD).
Mean optical density of inflammatory mediator ICAM-1 was 57.0 ± 27.1 (pixel values).
The number of VEGFR-2+ blood vessels and endothelial VEGFR-2 staining intensity were 6.2 ± 2.4 and 1.2 ± 0.8, respectively.
A positive association was found between endothelial VEGFR-2 staining intensity and the extent of inflammation (p=0.005).
Moreover, VEGFR-2 staining intensity correlated with the expression level of ICAM-1 (p=0.026).
The expression of VEGFR-2, one of the main targets of antiangiogenic therapy, depends on GBM microenvironment.
Higher endothelial VEGFR-2 levels were seen in the presence of more pronounced inflammation.
Target dependence on inflammatory tumor microenvironment has to be taken into consideration when treatment approaches that block VEGFR-2 signaling are designed.
American Psychological Association (APA)
Jaal, Jana& Kase, Marju& Minajeva, Ave& Saretok, Mikk& Adamson, Aidi& Junninen, Jelizaveta…[et al.]. 2015. VEGFR-2 Expression in Glioblastoma Multiforme Depends on Inflammatory Tumor Microenvironment. International Journal of Inflammation،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1066146
Modern Language Association (MLA)
Jaal, Jana…[et al.]. VEGFR-2 Expression in Glioblastoma Multiforme Depends on Inflammatory Tumor Microenvironment. International Journal of Inflammation No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1066146
American Medical Association (AMA)
Jaal, Jana& Kase, Marju& Minajeva, Ave& Saretok, Mikk& Adamson, Aidi& Junninen, Jelizaveta…[et al.]. VEGFR-2 Expression in Glioblastoma Multiforme Depends on Inflammatory Tumor Microenvironment. International Journal of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1066146
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1066146