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Curbing Inflammation in Multiple Sclerosis and Endometriosis: Should Mast Cells Be Targeted?
Author
Source
International Journal of Inflammation
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Inflammatory diseases and conditions can arise due to responses to a variety of external and internal stimuli.
They can occur acutely in response to some stimuli and then become chronic leading to tissue damage and loss of function.
While a number of cell types can be involved, mast cells are often present and can be involved in the acute and chronic processes.
Recent studies in porcine and rabbit models have supported the concept of a central role for mast cells in a “nerve-mast cell-myofibroblast axis” in some inflammatory processes leading to fibrogenic outcomes.
The current review is focused on the potential of extending aspects of this paradigm into treatments for multiple sclerosis and endometriosis, diseases not usually thought of as having common features, but both are reported to have activation of mast cells involved in their respective disease processes.
Based on the discussion, it is proposed that targeting mast cells in these diseases, particularly the early phases, may be a fruitful avenue to control the recurring inflammatory exacerbations of the conditions.
American Psychological Association (APA)
Hart, David A.. 2015. Curbing Inflammation in Multiple Sclerosis and Endometriosis: Should Mast Cells Be Targeted?. International Journal of Inflammation،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1066148
Modern Language Association (MLA)
Hart, David A.. Curbing Inflammation in Multiple Sclerosis and Endometriosis: Should Mast Cells Be Targeted?. International Journal of Inflammation No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1066148
American Medical Association (AMA)
Hart, David A.. Curbing Inflammation in Multiple Sclerosis and Endometriosis: Should Mast Cells Be Targeted?. International Journal of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1066148
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1066148