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Influence of Body Mass Index on Inflammatory Profile at Admission in Critically Ill Septic Patients
Joint Authors
Zampieri, Fernando G.
Jacob, Vanessa
Barbeiro, Hermes V.
Pinheiro da Silva, Fabiano
Souza, Heraldo P. de
Source
International Journal of Inflammation
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
Inflammation is ubiquitous during sepsis and may be influenced by body mass index (BMI).
We sought to evaluate if BMI was associated with serum levels of several cytokines measured at intensive care unit admission due to sepsis.
Methods.
33 septic patients were included.
An array of thirty-two cytokines and chemokines was measured using Milliplex technology.
We assessed the association between cytokine levels and BMI by generalized additive model that also included illness severity (measured by SAPS 3 score); one model was built for each cytokine measured.
Results.
We found that levels of epidermal growth factor, vascular endothelial growth factor, and interleukins 4, 5, and 13 were associated with BMI in a complex, nonlinear way, independently of illness severity.
Higher BMI was associated with higher levels of anti-inflammatory interleukins.
Conclusion.
BMI may influence host response to infection during critical illness.
Larger studies should confirm these findings.
American Psychological Association (APA)
Zampieri, Fernando G.& Jacob, Vanessa& Barbeiro, Hermes V.& Pinheiro da Silva, Fabiano& Souza, Heraldo P. de. 2015. Influence of Body Mass Index on Inflammatory Profile at Admission in Critically Ill Septic Patients. International Journal of Inflammation،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1066151
Modern Language Association (MLA)
Zampieri, Fernando G.…[et al.]. Influence of Body Mass Index on Inflammatory Profile at Admission in Critically Ill Septic Patients. International Journal of Inflammation No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1066151
American Medical Association (AMA)
Zampieri, Fernando G.& Jacob, Vanessa& Barbeiro, Hermes V.& Pinheiro da Silva, Fabiano& Souza, Heraldo P. de. Influence of Body Mass Index on Inflammatory Profile at Admission in Critically Ill Septic Patients. International Journal of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1066151
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1066151