Rapid Identification of Pathogens in Positive Blood Culture of Patients with Sepsis: Review and Meta-Analysis of the Performance of the Sepsityper Kit
Joint Authors
Morgenthaler, Nils G.
Kostrzewa, Markus
Source
International Journal of Microbiology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Sepsis is one of the leading causes of deaths, and rapid identification (ID) of blood stream infection is mandatory to perform adequate antibiotic therapy.
The advent of MALDI-TOF Mass Spectrometry for the rapid ID of pathogens was a major breakthrough in microbiology.
Recently, this method was combined with extraction methods for pathogens directly from positive blood cultures.
This review summarizes the results obtained so far with the commercial Sepsityper sample preparation kit, which is now approved for in vitro diagnostic use.
Summarizing data from 21 reports, the Sepsityper kit allowed a reliable ID on the species level of 80% of 3320 positive blood culture bottles.
Gram negative bacteria resulted consistently in higher ID rates (90%) compared to Gram positive bacteria (76%) or yeast (66%).
No relevant misidentifications on the genus level were reported at a log(score)cut-off of 1.6.
The Sepsityper kit is a simple and reproducible method which extends the MALDI-TOF technology to positive blood culture specimens and shortens the time to result by several hours or even days.
In combination with antibiotic stewardship programs, this rapid ID allows a much faster optimization of antibiotic therapy in patients with sepsis compared to conventional workflows.
American Psychological Association (APA)
Morgenthaler, Nils G.& Kostrzewa, Markus. 2015. Rapid Identification of Pathogens in Positive Blood Culture of Patients with Sepsis: Review and Meta-Analysis of the Performance of the Sepsityper Kit. International Journal of Microbiology،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1066179
Modern Language Association (MLA)
Morgenthaler, Nils G.& Kostrzewa, Markus. Rapid Identification of Pathogens in Positive Blood Culture of Patients with Sepsis: Review and Meta-Analysis of the Performance of the Sepsityper Kit. International Journal of Microbiology No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1066179
American Medical Association (AMA)
Morgenthaler, Nils G.& Kostrzewa, Markus. Rapid Identification of Pathogens in Positive Blood Culture of Patients with Sepsis: Review and Meta-Analysis of the Performance of the Sepsityper Kit. International Journal of Microbiology. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1066179
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1066179