Spot Urine Estimations Are Equivalent to 24-Hour Urine Assessments of Urine Protein Excretion for Predicting Clinical Outcomes
Joint Authors
Loh, Ping Tyug
Wong, Weng Kin
Ho, Peh Joo
Choi, Kwok Pui
Xu, Hui
Lau, Titus
Lee, Evan J. C.
Sethi, Sunil
Toh, Qi Chun
Saw, Sharon
Teo, Boon Wee
Source
International Journal of Nephrology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
The use of spot urine protein to creatinine ratios in estimating 24 hr urine protein excretion rates for diagnosing and managing chronic kidney disease (CKD) predated the standardization of creatinine assays.
The comparative predictive performance of spot urine ratios and 24 hr urine collections (of albumin or protein) for the clinical outcomes of CKD progression, end-stage renal disease (ESRD), and mortality in Asians is unclear.
We compared 4 methods of assessing urine protein excretion in a multiethnic population of CKD patients.
Methods.
Patients with CKD ( n = 232 ) provided 24 hr urine collections followed by spot urine samples the next morning.
We created multiple linear regression models to assess the factors associated with GFR decline (median follow-up: 37 months, IQR 26–41) and constructed Cox proportional-hazards models for predicting the combined outcome of ESRD and death.
Results.
The linear regression models showed that 24 hr urine protein excretion was most predictive of GFR decline but all other methods were similar.
For the combined outcomes of ESRD and death, the proportional hazards models had similar predictive performance.
Conclusions.
We showed that all methods of assessments were comparable for clinical end-points, and any method can be used in clinical practice or research.
American Psychological Association (APA)
Teo, Boon Wee& Loh, Ping Tyug& Wong, Weng Kin& Ho, Peh Joo& Choi, Kwok Pui& Toh, Qi Chun…[et al.]. 2015. Spot Urine Estimations Are Equivalent to 24-Hour Urine Assessments of Urine Protein Excretion for Predicting Clinical Outcomes. International Journal of Nephrology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1066224
Modern Language Association (MLA)
Teo, Boon Wee…[et al.]. Spot Urine Estimations Are Equivalent to 24-Hour Urine Assessments of Urine Protein Excretion for Predicting Clinical Outcomes. International Journal of Nephrology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1066224
American Medical Association (AMA)
Teo, Boon Wee& Loh, Ping Tyug& Wong, Weng Kin& Ho, Peh Joo& Choi, Kwok Pui& Toh, Qi Chun…[et al.]. Spot Urine Estimations Are Equivalent to 24-Hour Urine Assessments of Urine Protein Excretion for Predicting Clinical Outcomes. International Journal of Nephrology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1066224
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1066224