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Prognostic Value of Serum Uric Acid in Patients on the Waiting List before and after Renal Transplantation
Joint Authors
Muela, Henrique Cotchi Simbo
De Lima, Jose Jayme Galvão
Gowdak, Luis Henrique W.
de Paula, Flávio J.
Bortolotto, Luiz Aparecido
Source
International Journal of Nephrology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
High serum uric acid (UA) is associated with increased cardiovascular (CV) risk in the general population.
The impact of UA on CV events and mortality in CKD is unclear.
Objective.
To assess the relationship between UA and prognosis in hemodialysis (HD) patients before and after renal transplantation (TX).
Methods.
1020 HD patients assessed for CV risk and followed from the time of inception until CV event, death, or TX (HD) or date of TX, CV event, death, or return to dialysis (TX).
Results.
821 patients remained on HD while 199 underwent TX.
High UA (≥428 mmol/L) was not associated with either composite CV events or mortality in HD patients.
In TX patients high UA predicted an increased risk of events ( P = 0.03 , HR 1.6, and 95% CI 1.03–2.54) but not with death.
In the Cox proportional model UA was no longer significantly associated with CV events.
Instead, a reduced GFR (<50 mL/min) emerged as the independent risk factor for events ( P = 0.02 , HR 1.79, and % CI 1.07–3.21).
Conclusion.
In recipients of TX an increased posttransplant UA is related to higher probability of major CV events but this association probably caused concurrent reduction in GFR.
American Psychological Association (APA)
Muela, Henrique Cotchi Simbo& De Lima, Jose Jayme Galvão& Gowdak, Luis Henrique W.& de Paula, Flávio J.& Bortolotto, Luiz Aparecido. 2015. Prognostic Value of Serum Uric Acid in Patients on the Waiting List before and after Renal Transplantation. International Journal of Nephrology،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1066229
Modern Language Association (MLA)
Muela, Henrique Cotchi Simbo…[et al.]. Prognostic Value of Serum Uric Acid in Patients on the Waiting List before and after Renal Transplantation. International Journal of Nephrology No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1066229
American Medical Association (AMA)
Muela, Henrique Cotchi Simbo& De Lima, Jose Jayme Galvão& Gowdak, Luis Henrique W.& de Paula, Flávio J.& Bortolotto, Luiz Aparecido. Prognostic Value of Serum Uric Acid in Patients on the Waiting List before and after Renal Transplantation. International Journal of Nephrology. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1066229
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1066229