The Effects of Simvastatin on Proteinuria and Renal Function in Patients with Chronic Kidney Disease
Joint Authors
Satirapoj, Bancha
Promrattanakun, Anan
Supasyndh, Ouppatham
Choovichian, Panbuppa
Source
International Journal of Nephrology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Current data suggests that statins might have beneficial effects on renal outcomes.
Beneficial effects of statin treatment on renal progression in advanced chronic kidney disease (CKD) are obviously controversial.
In a retrospective, controlled study, the authors have evaluated the effects of 53-week treatment with simvastatin, versus no treatment on proteinuria and renal function among 51 patients with CKD stages III-IV.
By the end of the 53-week treatment, urine protein excretion decreased from 0.96 (IQR 0.54, 2.9) to 0.48 (IQR 0.18, 0.79) g/g creatinine (P<0.001) in patients treated with simvastatin in addition to ACEI and ARBs, while no change was observed among the untreated patients.
Moreover, a significantly greater decrease in urine protein excretion was observed in the simvastatin group as compared with the untreated group.
The mean changes of serum creatinine and eGFR did not significantly differ in both groups.
A significantly greater decrease in total cholesterol and LDL-cholesterol was found in the simvastatin group than in the untreated group.
In summary, apart from lipid lowering among CKD patients, ingesting simvastatin was associated with a decrease in proteinuria.
These statin effects may become important for supportive therapy in renal damage in the future.
American Psychological Association (APA)
Satirapoj, Bancha& Promrattanakun, Anan& Supasyndh, Ouppatham& Choovichian, Panbuppa. 2015. The Effects of Simvastatin on Proteinuria and Renal Function in Patients with Chronic Kidney Disease. International Journal of Nephrology،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1066230
Modern Language Association (MLA)
Satirapoj, Bancha…[et al.]. The Effects of Simvastatin on Proteinuria and Renal Function in Patients with Chronic Kidney Disease. International Journal of Nephrology No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1066230
American Medical Association (AMA)
Satirapoj, Bancha& Promrattanakun, Anan& Supasyndh, Ouppatham& Choovichian, Panbuppa. The Effects of Simvastatin on Proteinuria and Renal Function in Patients with Chronic Kidney Disease. International Journal of Nephrology. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1066230
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1066230