The Clinical Efficacy and Safety of Ertapenem for the Treatment of Complicated Urinary Tract Infections Caused by ESBL-Producing Bacteria in Children
Joint Authors
Karaaslan, Ayse
Soysal, Ahmet
Bakır, Mustafa
Öcal Demir, Sevliya
Akkoc, Gulsen
Yakut, Nurhayat
Atici, Serkan
Kepenekli Kadayifci, Eda
Source
International Journal of Nephrology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-27
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
Urinary tract infections (UTIs) are common and important clinical problem in childhood, and extended-spectrum-beta-lactamase- (ESBL-) producing organisms are the leading cause of healthcare-related UTIs.
In this study, we aimed to evaluate the clinical efficacy and safety of ertapenem therapy in children with complicated UTIs caused by ESBL-producing organisms.
Methods.
Seventy-seven children with complicated UTIs caused by ESBL-producing organisms were included in this retrospective study, and all had been treated with ertapenem between January 2013 and June 2014.
Results.
Sixty-one (79%) females and sixteen (21%) males with a mean ± standard deviation (SD) age of 76.6 ± 52 months (range 3–204, median 72 months) were enrolled in this study.
Escherichia coli (E.
coli) ( n = 67 ; 87%) was the most common bacterial cause of the UTIs followed by Klebsiella pneumoniae (K.
pneumoniae) ( n = 9 ; 11.7%) and Enterobacter cloacae (E.
cloacae) ( n = 1 ; 1.3%).
The mean duration of the ertapenem therapy was 8.9 ± 1.6 days (range 4–11).
No serious drug-related clinical or laboratory adverse effects were observed, and the ertapenem therapy was found to be safe and well tolerated in the children in our study.
Conclusion.
Ertapenem is a newer carbapenem with the advantage of once-daily dosing and is highly effective for treating UTIs caused by ESBL-producing microorganisms.
American Psychological Association (APA)
Karaaslan, Ayse& Kepenekli Kadayifci, Eda& Atici, Serkan& Akkoc, Gulsen& Yakut, Nurhayat& Öcal Demir, Sevliya…[et al.]. 2015. The Clinical Efficacy and Safety of Ertapenem for the Treatment of Complicated Urinary Tract Infections Caused by ESBL-Producing Bacteria in Children. International Journal of Nephrology،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1066234
Modern Language Association (MLA)
Karaaslan, Ayse…[et al.]. The Clinical Efficacy and Safety of Ertapenem for the Treatment of Complicated Urinary Tract Infections Caused by ESBL-Producing Bacteria in Children. International Journal of Nephrology No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1066234
American Medical Association (AMA)
Karaaslan, Ayse& Kepenekli Kadayifci, Eda& Atici, Serkan& Akkoc, Gulsen& Yakut, Nurhayat& Öcal Demir, Sevliya…[et al.]. The Clinical Efficacy and Safety of Ertapenem for the Treatment of Complicated Urinary Tract Infections Caused by ESBL-Producing Bacteria in Children. International Journal of Nephrology. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1066234
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1066234