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The Impact of Ethnicity on Wilms Tumor: Characteristics and Outcome of a South African Cohort
Joint Authors
Stefan, D. C.
Stones, D. K.
Hadley, G. P.
Wainwright, R. D.
Source
International Journal of Pediatrics
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-26
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Nephroblastoma is the commonest renal tumour seen in children.
It has a good prognosis in developed countries with survival rates estimated to be between 80% and 90%, while in Africa it remains low.
Method.
Retrospective study of patients diagnosed with nephroblastoma who are seen at 4 paediatric oncology units, representing 58.5% of all South African children with nephroblastoma and treated following SIOP protocol between January 2000 and December 2010.
Results.
A total of 416 patients were seen at the 4 units.
Over 80% of our patients were African and almost 10% of mixed ethnicity.
The most common stage was stage 4.
The median survival was 28 months after diagnosis with the mixed ethnicity patients recording the longest duration (39 months) and the white patients had the shortest median survival.
The overall 5-year survival rate was estimated to be 66%.
Stage 2 patients did significantly better (85%).
Conclusions.
Our patients are similar with regard to gender ratio, median age, and age distribution as described in the literature, but in South Africa the more advanced stage disease seen than in other developed countries is translated into low overall survival rate.
American Psychological Association (APA)
Stones, D. K.& Hadley, G. P.& Wainwright, R. D.& Stefan, D. C.. 2015. The Impact of Ethnicity on Wilms Tumor: Characteristics and Outcome of a South African Cohort. International Journal of Pediatrics،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1066700
Modern Language Association (MLA)
Stones, D. K.…[et al.]. The Impact of Ethnicity on Wilms Tumor: Characteristics and Outcome of a South African Cohort. International Journal of Pediatrics No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1066700
American Medical Association (AMA)
Stones, D. K.& Hadley, G. P.& Wainwright, R. D.& Stefan, D. C.. The Impact of Ethnicity on Wilms Tumor: Characteristics and Outcome of a South African Cohort. International Journal of Pediatrics. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1066700
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1066700