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Synthesis and Characterization of Chemically Cross-Linked Acrylic AcidGelatin Hydrogels: Effect of pH and Composition on Swelling and Drug Release
Joint Authors
Bukhari, Syed Majid Hanif
Khan, Samiullah
Rehanullah, Muhammad
Ranjha, Nazar Mohammad
Source
International Journal of Polymer Science
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-07
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
This present work was aimed at synthesizing pH-sensitive cross-linked AA/Gelatin hydrogels by free radical polymerization.
Ammonium persulfate and ethylene glycol dimethacrylate (EGDMA) were used as initiator and as cross-linking agent, respectively.
Different feed ratios of acrylic acid, gelatin, and EGDMA were used to investigate the effect of monomer, polymer, and degree of cross-linking on swelling and release pattern of the model drug.
The swelling behavior of the hydrogel samples was studied in 0.05 M USP phosphate buffer solutions of various pH values pH 1.2, pH 5.5, pH 6.5, and pH 7.5.
The prepared samples were evaluated for porosity and sol-gel fraction analysis.
Pheniramine maleate used for allergy treatment was loaded as model drug in selected samples.
The release study of the drug was investigated in 0.05 M USP phosphate buffer of varying pH values (1.2, 5.5, and 7.5) for 12 hrs.
The release data was fitted to various kinetic models to study the release mechanism.
Hydrogels were characterized by Fourier transformed infrared (FTIR) spectroscopy which confirmed formation of structure.
Surface morphology of unloaded and loaded samples was studied by surface electron microscopy (SEM), which confirmed the distribution of model drug in the gel network.
American Psychological Association (APA)
Bukhari, Syed Majid Hanif& Khan, Samiullah& Rehanullah, Muhammad& Ranjha, Nazar Mohammad. 2015. Synthesis and Characterization of Chemically Cross-Linked Acrylic AcidGelatin Hydrogels: Effect of pH and Composition on Swelling and Drug Release. International Journal of Polymer Science،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1066726
Modern Language Association (MLA)
Bukhari, Syed Majid Hanif…[et al.]. Synthesis and Characterization of Chemically Cross-Linked Acrylic AcidGelatin Hydrogels: Effect of pH and Composition on Swelling and Drug Release. International Journal of Polymer Science No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1066726
American Medical Association (AMA)
Bukhari, Syed Majid Hanif& Khan, Samiullah& Rehanullah, Muhammad& Ranjha, Nazar Mohammad. Synthesis and Characterization of Chemically Cross-Linked Acrylic AcidGelatin Hydrogels: Effect of pH and Composition on Swelling and Drug Release. International Journal of Polymer Science. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1066726
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1066726