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Sulfated Alkyl Glucopyranans with Potent Antiviral Activity Synthesized by Ring-Opening Copolymerization of Anhydroglucose and Alkyl Anhydroglucose Monomers
Joint Authors
Bai, Shiming
Budragchaa, Davaanyam
Han, Shuqin
Kanamoto, Taisei
Nakashima, Hideki
Yoshida, Takashi
Source
International Journal of Polymer Science
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Sulfated glucopyranans having long alkyl groups were prepared by the ring-opening copolymerization of benzylated 1,6-anhydroglucopyranose with 3-O-octadecyl 1,6-anhydro-β-d-glucopyranose monomers, and subsequent deprotection and sulfation.
Water-soluble sulfated glucopyranans with 2.8 and 4.7 mol% of 3-O-octadecyl group and lower molecular weights of M-n = 2.5 × 103–5.1 × 103 have potent anti-HIV activity at 0.05–1.25 μg/mL, even though sulfated polysaccharides with molecular weights below M-n = 6 × 103 had low anti-HIV activity.
The interaction with poly-l-lysine as a model compound of proteins was analyzed by SPR, DSL, and zeta potential, indicating that the sulfated 3-O-octadecyl glucopyranans had high association and low dissociation rate constants, and the particle size increased after addition of poly-l-lysine.
The anti-HIV activity was induced by electrostatic interaction between sulfate groups and amino groups of poly-l-lysine and by the synergistic effect of the hydrophobic long alkyl chain and hydrophilic sulfated group.
American Psychological Association (APA)
Bai, Shiming& Budragchaa, Davaanyam& Han, Shuqin& Kanamoto, Taisei& Nakashima, Hideki& Yoshida, Takashi. 2015. Sulfated Alkyl Glucopyranans with Potent Antiviral Activity Synthesized by Ring-Opening Copolymerization of Anhydroglucose and Alkyl Anhydroglucose Monomers. International Journal of Polymer Science،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1066754
Modern Language Association (MLA)
Bai, Shiming…[et al.]. Sulfated Alkyl Glucopyranans with Potent Antiviral Activity Synthesized by Ring-Opening Copolymerization of Anhydroglucose and Alkyl Anhydroglucose Monomers. International Journal of Polymer Science No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1066754
American Medical Association (AMA)
Bai, Shiming& Budragchaa, Davaanyam& Han, Shuqin& Kanamoto, Taisei& Nakashima, Hideki& Yoshida, Takashi. Sulfated Alkyl Glucopyranans with Potent Antiviral Activity Synthesized by Ring-Opening Copolymerization of Anhydroglucose and Alkyl Anhydroglucose Monomers. International Journal of Polymer Science. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1066754
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1066754