Development of Cutaneous Bioadhesive Ureasil-Polyether Hybrid Films
Joint Authors
Oshiro Junior, João Augusto
Carvalho, Flávia Chiva
Soares, Christiane Pienna
Chorilli, Marlus
Chiavacci, Leila Aparecida
Source
International Journal of Polymer Science
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The hydrolysis and condensation reactions involved in synthesis of ureasil-polyether films influence the film formation time and the number of chemical groups able to form hydrogen bonds, responsible for the bioadhesion, with the biological substrate.
The objective of this work was to study the influence of the use of an acid catalyst (hydrochloric acid) and a basic catalyst (ammonium fluoride) in the hydrolysis and condensation reactions on the time formation and bioadhesion of ureasil-polyether films.
The toxicity of the films was evaluated.
The MTT assay has shown cell viability of human skin keratinocytes higher than 70% of all analyzed materials suggesting low cytotoxicity.
The bioadhesion of the films is strongly dependent on the viscosity and hydrophilic/hydrophobic balance of the polyether chains used to synthetize the hybrid molecules.
The use of acid catalyst promotes the formation of less viscous films with higher bioadhesion.
The hybrids formed by more hydrophilic PEO chains are more bioadherent, since they can interact more efficiently with the water present in the stratum corneum increasing the bioadhesion.
Due to their low toxicity and high bioadhesion, the ureasil-PEO films obtained by using HCl as catalyst agent are good candidates for application to the skin as bioadhesive films.
American Psychological Association (APA)
Oshiro Junior, João Augusto& Carvalho, Flávia Chiva& Soares, Christiane Pienna& Chorilli, Marlus& Chiavacci, Leila Aparecida. 2015. Development of Cutaneous Bioadhesive Ureasil-Polyether Hybrid Films. International Journal of Polymer Science،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1066827
Modern Language Association (MLA)
Oshiro Junior, João Augusto…[et al.]. Development of Cutaneous Bioadhesive Ureasil-Polyether Hybrid Films. International Journal of Polymer Science No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1066827
American Medical Association (AMA)
Oshiro Junior, João Augusto& Carvalho, Flávia Chiva& Soares, Christiane Pienna& Chorilli, Marlus& Chiavacci, Leila Aparecida. Development of Cutaneous Bioadhesive Ureasil-Polyether Hybrid Films. International Journal of Polymer Science. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1066827
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1066827