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Designing of Collagen Based Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) Scaffolds for Tissue Engineering
Joint Authors
Abdullah, Amirul Al-Ashraf
Vigneswari, S.
Abdul Khalil, H. P. S.
Source
International Journal of Polymer Science
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
P(3HB-co-4HB) copolymer was modified using collagen by adapting dual solvent system.
The surface properties of samples were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), organic elemental analysis (CHN analysis), and water contact angle measurements.
The effects of collagen concentration, scaffold thickness, and 4HB molar fraction on the hydrophilicity were optimized by the Taguchi method.
The orthogonal array experiment was conducted to obtain the response for a hydrophilic scaffold.
Analysis of variance (ANOVA) was used to determine the significant parameters and determine the optimal level for each parameter.
The results also showed that the hydrophilicity of P(3HB-co-4HB)/collagen blend scaffolds increased as the collagen concentration increased up to 15 wt% with a molar fraction of 50 mol% at 0.1 mm scaffold thickness.
The biocompatibility of the P(3HB-co-4HB)/collagen blend surface was evaluated by fibroblast cell (L929) culture.
The collagen blend scaffold surfaces showed significant cell adhesion and growth as compared to P(3HB-co-4HB) copolymer scaffolds.
American Psychological Association (APA)
Vigneswari, S.& Abdul Khalil, H. P. S.& Abdullah, Amirul Al-Ashraf. 2015. Designing of Collagen Based Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) Scaffolds for Tissue Engineering. International Journal of Polymer Science،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1066830
Modern Language Association (MLA)
Vigneswari, S.…[et al.]. Designing of Collagen Based Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) Scaffolds for Tissue Engineering. International Journal of Polymer Science No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1066830
American Medical Association (AMA)
Vigneswari, S.& Abdul Khalil, H. P. S.& Abdullah, Amirul Al-Ashraf. Designing of Collagen Based Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) Scaffolds for Tissue Engineering. International Journal of Polymer Science. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1066830
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1066830