Gynaecological Screening for Cervical and Vulvar Malignancies in a Cohort of Systemic Sclerosis Patients: Our Experience and Review of the Literature
Joint Authors
Sebastiani, Marco
Manfredi, Andreina
Campomori, Federica
Giuggioli, Dilia
Vacchi, C.
Boselli, F.
Ferri, C.
Cassone, Giulia
Colaci, Michele
Source
International Journal of Rheumatology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-18
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Increased incidence of cancer was frequently reported in scleroderma (SSc), but no association with gynaecological malignancies was described in literature.
Objectives.
To investigate gynaecological neoplasms in SSc patients.
Methods.
In this cross-sectional analysis, we evaluated 80 SSc patients, living in the same geographical area.
We considered all patients undergoing gynaecological evaluation, including pap test as screening for cervical cancer, between January 2008 and December 2014.
Results.
55 (68.7%) patients were negative and 20 (25%) presented inflammatory alterations, while cancer or precancerous lesions were found in 5 (6.2%) cases (2 showed cervical cancer (one of them in situ), 1 vulvar melanoma, 1 vulvar intraepithelial neoplasia, and 1 endocervical polyp with immature squamous metaplasia).
The frequency of cervical cancer in our series seems higher in comparison to the incidence registered in the same geographical area.
The presence of atypical cytological findings correlated with anti-Scl70 autoantibodies (p = 0.022); moreover, the patients with these alterations tended to be older (median 65, range 46–67), if compared to the whole series (p = 0.052).
Conclusions.
A relatively high frequency of gynaecological malignancies was found in our SSc series.
In general, gynaecological evaluation for SSc women needs to be included in the routine patients’ surveillance.
American Psychological Association (APA)
Colaci, Michele& Giuggioli, Dilia& Cassone, Giulia& Vacchi, C.& Campomori, Federica& Boselli, F.…[et al.]. 2015. Gynaecological Screening for Cervical and Vulvar Malignancies in a Cohort of Systemic Sclerosis Patients: Our Experience and Review of the Literature. International Journal of Rheumatology،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1066891
Modern Language Association (MLA)
Colaci, Michele…[et al.]. Gynaecological Screening for Cervical and Vulvar Malignancies in a Cohort of Systemic Sclerosis Patients: Our Experience and Review of the Literature. International Journal of Rheumatology No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1066891
American Medical Association (AMA)
Colaci, Michele& Giuggioli, Dilia& Cassone, Giulia& Vacchi, C.& Campomori, Federica& Boselli, F.…[et al.]. Gynaecological Screening for Cervical and Vulvar Malignancies in a Cohort of Systemic Sclerosis Patients: Our Experience and Review of the Literature. International Journal of Rheumatology. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1066891
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1066891