Determination of Early and Late Endothelial Progenitor Cells in Peripheral Circulation and Their Clinical Association with Coronary Artery Disease
Joint Authors
Tagawa, Shotoku
Nakanishi, Chiaki
Mori, Masayuki
Yoshida, Shohei
Shimojima, Masaya
Yokawa, Junichiro
Yoshimuta, Tsuyoshi
Kawashiri, Masaaki
Hayashi, Kenshi
Yamagishi, Masakazu
Source
International Journal of Vascular Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The clinical implications of early and late endothelial progenitor cells (EPCs) in coronary artery disease (CAD) remain unclear.
We investigated endothelial dysfunction in CAD by simultaneously examining early and late EPC colony formation and gene expression of specific surface markers in EPCs.
EPCs were extracted from a total of 83 subjects with (n=47) and without (n=36) CAD.
Early and late EPC colonies were formed from mononuclear cells extracted from peripheral blood.
We found that fewer early EPC colonies were produced in the CAD group (7.2 ± 3.l/well) than those in the control group (12.4 ± 1.4/well, p<0.05), and more late EPC colonies were produced in the CAD group (0.8 ± 0.2/well) than those in the control group (0.25 ± 0.02/well, p<0.05).
In the CAD group, the relative expression of CD31 and KDR of early and late EPCs was lower than in the control group.
These results demonstrate that CAD patients could have increased late EPC density and that early and late EPCs in CAD patients exhibited immature endothelial characteristics.
We suggest that changes in EPC colony count and gene expression of endothelial markers may have relation with development of CAD.
American Psychological Association (APA)
Tagawa, Shotoku& Nakanishi, Chiaki& Mori, Masayuki& Yoshimuta, Tsuyoshi& Yoshida, Shohei& Shimojima, Masaya…[et al.]. 2015. Determination of Early and Late Endothelial Progenitor Cells in Peripheral Circulation and Their Clinical Association with Coronary Artery Disease. International Journal of Vascular Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1066986
Modern Language Association (MLA)
Tagawa, Shotoku…[et al.]. Determination of Early and Late Endothelial Progenitor Cells in Peripheral Circulation and Their Clinical Association with Coronary Artery Disease. International Journal of Vascular Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1066986
American Medical Association (AMA)
Tagawa, Shotoku& Nakanishi, Chiaki& Mori, Masayuki& Yoshimuta, Tsuyoshi& Yoshida, Shohei& Shimojima, Masaya…[et al.]. Determination of Early and Late Endothelial Progenitor Cells in Peripheral Circulation and Their Clinical Association with Coronary Artery Disease. International Journal of Vascular Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1066986
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1066986