Elevated Circulating Levels of Inflammatory Markers in Patients with Acute Coronary Syndrome
Joint Authors
Shimada, Kazunori
Miyauchi, Katsumi
Al Shahi, Hamad
Yoshihara, Takuma
Sai, Eiryu
Shiozawa, Tomoyuki
Naito, Ryo
Aikawa, Tatsuro
Ouchi, Shohei
Kadoguchi, Tomoyasu
Miyazaki, Tetsuro
Daida, Hiroyuki
Source
International Journal of Vascular Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
We evaluated inflammatory cytokines and chemokine in peripheral blood mononuclear cells (PBMCs) in patients with either acute coronary syndrome (ACS) or stable coronary artery disease (CAD).
Methods.
We enrolled 20 ACS patients and 50 stable CAD patients without previous history of ACS who underwent cardiac catheterization.
Patients with an estimated glomerular filtration rate of ≤30 mL/min/1.73 m2 and C-reactive protein of ≥1.0 mg/dL were excluded.
Blood samples were collected from the patients just before catheterization, and PBMCs were isolated from the whole blood.
The levels of inflammatory cytokines and chemokine were measured by using real-time quantitative polymerase chain reaction and immunoassays.
Results.
The expression of tumor necrosis factor alpha (TNF-α), interleukin- (IL-) 6, IL-10, IL-23A, IL-27, and IL-37 was significantly higher in the ACS group than in the CAD group (P<0.05).
In contrast, the expression of IL-33 was significantly lower in the ACS group than in the CAD group (P<0.05).
The ACS patients had higher plasma levels of TNF-α, IL-6, and IL-10 in the ACS group than in the CAD group.
Conclusion.
Circulating levels of pro-/anti-inflammatory cytokines, including IL-23A, IL-27, IL-33, and IL-37, may be associated with the pathogenesis of atherosclerosis in ACS patients.
American Psychological Association (APA)
Al Shahi, Hamad& Shimada, Kazunori& Miyauchi, Katsumi& Yoshihara, Takuma& Sai, Eiryu& Shiozawa, Tomoyuki…[et al.]. 2015. Elevated Circulating Levels of Inflammatory Markers in Patients with Acute Coronary Syndrome. International Journal of Vascular Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1066988
Modern Language Association (MLA)
Al Shahi, Hamad…[et al.]. Elevated Circulating Levels of Inflammatory Markers in Patients with Acute Coronary Syndrome. International Journal of Vascular Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1066988
American Medical Association (AMA)
Al Shahi, Hamad& Shimada, Kazunori& Miyauchi, Katsumi& Yoshihara, Takuma& Sai, Eiryu& Shiozawa, Tomoyuki…[et al.]. Elevated Circulating Levels of Inflammatory Markers in Patients with Acute Coronary Syndrome. International Journal of Vascular Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1066988
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1066988