Vascular Leakage in Dengue Hemorrhagic Fever Is Associated with Dengue Infected Monocytes, Monocyte ActivationExhaustion, and Cytokines Production
Joint Authors
Chunhakan, Sirichan
Butthep, Punnee
Yoksan, Sutee
Tangnararatchakit, Kanchana
Chuansumrit, Ampaiwan
Source
International Journal of Vascular Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The vascular leakage was shown by the increment of hematocrit (Hct), dengue viral infected monocyte, monocyte status, and cytokines production in patients infected with dengue virus.
Dengue viral antigens were demonstrated in monocytes (CD14+) from peripheral blood mononuclear cells.
The increased levels of Hct, interleukin- (IL-) 10, and tumor necrosis factor-alpha (TNF-α) were detected in dengue fever (DF), dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) patients as compared with other febrile illnesses (OFIs).
The highest levels of Hct and IL-10 were detected in DSS patients as compared with other groups ( P < 0.05 ) especially on one day before and after defervescence.
The unstimulated and lipopolysaccharide- (LPS-) stimulated monocytes from DSS patients showed the significantly decreased of intracellular IL-1β and TNF-α.
In addition, the lowest level of mean fluorescence intensity (MFI) of CD11b expression on monocytes surface in DSS patients was also demonstrated.
Furthermore, the negative correlations between IL-10 levels and intracellular IL-1β and MFI of CD11b expression in unstimulated and LPS-stimulated monocytes were also detected.
Nevertheless, not only were the relationships between the prominent IL-10 and the suppression of intracellular monocyte secretion, namely, IL-1β, TNF-α, demonstrated but also the effect of vascular leakage was observed.
American Psychological Association (APA)
Chunhakan, Sirichan& Butthep, Punnee& Yoksan, Sutee& Tangnararatchakit, Kanchana& Chuansumrit, Ampaiwan. 2015. Vascular Leakage in Dengue Hemorrhagic Fever Is Associated with Dengue Infected Monocytes, Monocyte ActivationExhaustion, and Cytokines Production. International Journal of Vascular Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1066990
Modern Language Association (MLA)
Chunhakan, Sirichan…[et al.]. Vascular Leakage in Dengue Hemorrhagic Fever Is Associated with Dengue Infected Monocytes, Monocyte ActivationExhaustion, and Cytokines Production. International Journal of Vascular Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1066990
American Medical Association (AMA)
Chunhakan, Sirichan& Butthep, Punnee& Yoksan, Sutee& Tangnararatchakit, Kanchana& Chuansumrit, Ampaiwan. Vascular Leakage in Dengue Hemorrhagic Fever Is Associated with Dengue Infected Monocytes, Monocyte ActivationExhaustion, and Cytokines Production. International Journal of Vascular Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1066990
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1066990