Determination of Matrine in Rat Plasma after Oral Administration of Novel Korean Herbal Medicine KIOM-MA128 and Application of PK
Joint Authors
Ma, Jin Yeul
Back, Hyun-moon
Song, Byungjeong
Chae, Jung-woo
Yun, Hwi-yeol
Kwon, Kwang-il
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
KIOM-MA128 is a novel Korean herbal medicine with antiatopic, anti-inflammatory, and antiasthmatic effects.
Matrine is thought to be a potential chemical marker of KIOM-MA128, but pharmacokinetic studies on KIOM-MA128 had not been performed.
This study describes a simple and rapid method using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) to determine the concentration of matrine in rats plasma after administration of KIOM-MA128.
The isocratic mobile phase consisted of methanol and distilled water, and the flow rate was 0.15 mL/min.
The accuracy and precision of the assay, as well as stability tests, were performed in accordance with FDA regulations for the validation of bioanalytical methods.
The half-life and T max of matrine after administration of KIOM-MA128 were 4.29 ± 2.20 h and 1.8 ± 1.23 h, respectively.
C max and AUC inf of matrine after administration of KIOM-MA128 at 4 g/kg and 8 g/kg were 595.10 ± 182.91 ng/mL, 5336.77 ± 1503.84 ng/mL·h and 850.46 ± 120 ng/mL, 9583.10 ± 888.92 ng/mL·h, respectively.
The validated method was successfully applied to a pharmacokinetic study in rats after oral administration of KIOM-MA128.
American Psychological Association (APA)
Back, Hyun-moon& Song, Byungjeong& Chae, Jung-woo& Yun, Hwi-yeol& Ma, Jin Yeul& Kwon, Kwang-il. 2015. Determination of Matrine in Rat Plasma after Oral Administration of Novel Korean Herbal Medicine KIOM-MA128 and Application of PK. Journal of Analytical Methods in Chemistry،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1067195
Modern Language Association (MLA)
Back, Hyun-moon…[et al.]. Determination of Matrine in Rat Plasma after Oral Administration of Novel Korean Herbal Medicine KIOM-MA128 and Application of PK. Journal of Analytical Methods in Chemistry No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1067195
American Medical Association (AMA)
Back, Hyun-moon& Song, Byungjeong& Chae, Jung-woo& Yun, Hwi-yeol& Ma, Jin Yeul& Kwon, Kwang-il. Determination of Matrine in Rat Plasma after Oral Administration of Novel Korean Herbal Medicine KIOM-MA128 and Application of PK. Journal of Analytical Methods in Chemistry. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1067195
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067195