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Protective Effects of Intralipid and Caffeic Acid Phenethyl Ester on Nephrotoxicity Caused by Dichlorvos in Rats
Joint Authors
Zemheri, Ebru
Alp, Ayse
Dokuyucu, Recep
Ertekin, Filiz
Yaldiz, Mehmet
Akdag, Abdurrahman
Ipci, Ozlem
Toprak, Serhat
Özkanlı, Şeyma
Celik, Muhammet Murat
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The protective effects of Caffeic Acid Phenethyl Ester (CAPE) and intralipid (IL) on nephrotoxicity caused by acute Dichlorvos (D) toxicity were investigated in this study.
Forty-eight Wistar Albino rats were divided into 7 groups as follows: Control, D, CAPE, intralipid, D + CAPE, D + IL, and D + CAPE + IL.
When compared to D group, the oxidative stress index (OSI) values were significantly lower in Control, CAPE, and D + IL + CAPE groups.
When compared to D + IL + CAPE group, the TOS and OSI values were significantly higher in D group (P<0.05).
When mitotic cell counts were assessed in the renal tissues, it was found that mitotic cell count was significantly higher in the D group while it was lower in the D + CAPE, D + IL, and D + IL + CAPE groups when compared to the control group (P<0.05).
Also, immune reactivity showed increased apoptosis in D group and low profile of apoptosis in the D + CAPE group when compared to the Control group.
The apoptosis level was significantly lower in D + IL + CAPE compared to D group (P<0.05) in the kidneys.
As a result, we concluded that Dichlorvos can be used either alone or in combination with CAPE and IL as supportive therapy or as facilitator for the therapeutic effect of the routine treatment in the patients presenting with pesticide poisoning.
American Psychological Association (APA)
Celik, Muhammet Murat& Alp, Ayse& Dokuyucu, Recep& Zemheri, Ebru& Özkanlı, Şeyma& Ertekin, Filiz…[et al.]. 2015. Protective Effects of Intralipid and Caffeic Acid Phenethyl Ester on Nephrotoxicity Caused by Dichlorvos in Rats. Journal of Analytical Methods in Chemistry،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067198
Modern Language Association (MLA)
Celik, Muhammet Murat…[et al.]. Protective Effects of Intralipid and Caffeic Acid Phenethyl Ester on Nephrotoxicity Caused by Dichlorvos in Rats. Journal of Analytical Methods in Chemistry No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1067198
American Medical Association (AMA)
Celik, Muhammet Murat& Alp, Ayse& Dokuyucu, Recep& Zemheri, Ebru& Özkanlı, Şeyma& Ertekin, Filiz…[et al.]. Protective Effects of Intralipid and Caffeic Acid Phenethyl Ester on Nephrotoxicity Caused by Dichlorvos in Rats. Journal of Analytical Methods in Chemistry. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067198
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067198