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Determination of Propranolol Hydrochloride in Pharmaceutical Preparations Using Near Infrared Spectrometry with Fiber Optic Probe and Multivariate Calibration Methods
Joint Authors
Muller, Aline Lima Hermes
Irineu Muller, Edson
Marques Junior, Jucelino Medeiros
Foletto, Edson Luiz
da Costa, Adilson Ben
Bizzi, Cezar Augusto
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
A method for determination of propranolol hydrochloride in pharmaceutical preparation using near infrared spectrometry with fiber optic probe (FTNIR/PROBE) and combined with chemometric methods was developed.
Calibration models were developed using two variable selection models: interval partial least squares (iPLS) and synergy interval partial least squares (siPLS).
The treatments based on the mean centered data and multiplicative scatter correction (MSC) were selected for models construction.
A root mean square error of prediction (RMSEP) of 8.2 mg g−1 was achieved using siPLS (s2i20PLS) algorithm with spectra divided into 20 intervals and combination of 2 intervals (8501 to 8801 and 5201 to 5501 cm−1).
Results obtained by the proposed method were compared with those using the pharmacopoeia reference method and significant difference was not observed.
Therefore, proposed method allowed a fast, precise, and accurate determination of propranolol hydrochloride in pharmaceutical preparations.
Furthermore, it is possible to carry out on-line analysis of this active principle in pharmaceutical formulations with use of fiber optic probe.
American Psychological Association (APA)
Marques Junior, Jucelino Medeiros& Muller, Aline Lima Hermes& Foletto, Edson Luiz& da Costa, Adilson Ben& Bizzi, Cezar Augusto& Irineu Muller, Edson. 2015. Determination of Propranolol Hydrochloride in Pharmaceutical Preparations Using Near Infrared Spectrometry with Fiber Optic Probe and Multivariate Calibration Methods. Journal of Analytical Methods in Chemistry،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1067238
Modern Language Association (MLA)
Marques Junior, Jucelino Medeiros…[et al.]. Determination of Propranolol Hydrochloride in Pharmaceutical Preparations Using Near Infrared Spectrometry with Fiber Optic Probe and Multivariate Calibration Methods. Journal of Analytical Methods in Chemistry No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1067238
American Medical Association (AMA)
Marques Junior, Jucelino Medeiros& Muller, Aline Lima Hermes& Foletto, Edson Luiz& da Costa, Adilson Ben& Bizzi, Cezar Augusto& Irineu Muller, Edson. Determination of Propranolol Hydrochloride in Pharmaceutical Preparations Using Near Infrared Spectrometry with Fiber Optic Probe and Multivariate Calibration Methods. Journal of Analytical Methods in Chemistry. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1067238
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067238