Optimization of Gentisides Extraction from Gentiana rigescens Franch. ex Hemsl. by Response Surface Methodology
Joint Authors
Wang, Yuanzhong
Chu, Bowen
Shi, Yao
Li, Zhimin
Tian, Hao
Li, Wanyi
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Gentisides are a class of chemical compounds which is considered as potential therapeutic substance for treatment of neurodegenerative disorders.
The heat reflux extraction conditions were optimized for seven kinds of gentisides from the root and rhizome of Gentiana rigescens Franch.
ex Hemsl.
by employing response surface method.
Based on univariate test, a Box-Behnken design (BBD) was applied to the survey of relationships between response value (gentisides yield) and independent variables which were chosen from various extraction processes, including extraction temperature, extraction time, and solvent-material ratio.
The optimized conditions for this extraction are as follows: extraction time of 3.40 h, extraction temperature of 74.33°C, and ratio of solvent to raw material of 10.21 : 1 mL/g.
Verification assay revealed that the predicted value (99.24%) of extraction parameters from this model was mainly conformed to the experimentally observed values ( 98.6 1 ± 0.6 1 ).
American Psychological Association (APA)
Chu, Bowen& Shi, Yao& Li, Zhimin& Tian, Hao& Li, Wanyi& Wang, Yuanzhong. 2015. Optimization of Gentisides Extraction from Gentiana rigescens Franch. ex Hemsl. by Response Surface Methodology. Journal of Analytical Methods in Chemistry،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067240
Modern Language Association (MLA)
Chu, Bowen…[et al.]. Optimization of Gentisides Extraction from Gentiana rigescens Franch. ex Hemsl. by Response Surface Methodology. Journal of Analytical Methods in Chemistry No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1067240
American Medical Association (AMA)
Chu, Bowen& Shi, Yao& Li, Zhimin& Tian, Hao& Li, Wanyi& Wang, Yuanzhong. Optimization of Gentisides Extraction from Gentiana rigescens Franch. ex Hemsl. by Response Surface Methodology. Journal of Analytical Methods in Chemistry. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067240
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067240